Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic profiles of type I/III interferon-responsive hair follicle subsets from WT with or without Poly:IC injection

ABSTRACT: Transcriptomic profiles of type I/III interferon-responsive hair follicle subsets from WT with or without Poly:IC injection

PROVIDER: PRJNA748254 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15197268.fastq.gz	Fastqsanger.gz
	SRR15197269.fastq.gz	Fastqsanger.gz
	SRR15197270.fastq.gz	Fastqsanger.gz
	SRR15197271.fastq.gz	Fastqsanger.gz
	SRR15197272.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Transcriptomic profiles of type I/III interferon-responsive keratinocyte subsets from WT with or without Poly:IC injection

Project description:Transcriptomic profiles of type I/III interferon-responsive keratinocyte subsets from WT with or without Poly:IC injection

| PRJNA749593 | ENA

Transcriptomic profiles of type I/III interferon-responsive hair follicle subsets from WT with or without Poly:IC injection

Project description:Inflammation triggered by viral infections can obscure tissue function. We utilized a model of systemic anti-viral immunity and found distinct type I IFN responses within the epidermal compartments.

2021-07-23 | GSE180435 | GEO

ZNF750 plays an important role in skin inflammation induced by POLY IC treatment

Project description:Loss of ZNF750 increased the inflammatory gene expression of differentiated human keratinocytes treated with POLY IC

2024-08-28 | GSE248486 | GEO

Less invasive diagnostics for cancer using hair follicle

Project description:Primary outcome(s): Comparison of the gene expression profile in hair follicle between cancer patients and healthy volunteer

| 2628246 | ecrin-mdr-crc

Transcriptional profile of WT, PRR and IFN-/- dendritic cells stimulated with poly IC in vivo

Project description:Analysis of the specific transcriptional changes on DCs provided by direct pattern recogition receptor (PRR) or IFNAR signaling that are required for DC maturation after poly IC stimulation. Results provide important information about the intricate differentiation process of DC maturation and the importance of type I IFNs for DC immunogenicity. WT/IFNA-/- or WT/PRR-/- mixed-chimera mice were injected with 50 ug Poly-IC i.p. in vivo 4 and 14 hr later, wild type and KO CD11chi CD3- DX5- B220- DCs were FACS sorted based on CD45.2 expression. Total RNA was isolated and expression profile was compared between unstimulated and activated WT and KO DCs.

2013-10-01 | E-GEOD-46478 | biostudies-arrayexpress

Human dermal endothelial cells co-treated with dsRNA mimic poly IC and antimicrobial peptide LL-37

Project description:Next generation sequencing (RNA-seq) was used to study the global effects of co-treatment of endothelial cells with poly IC and LL-37. This lead to identification of differentially regulated genes and enriched pathways

2019-04-02 | GSE129152 | GEO

Transcription profiling of primary human astrocytes from brain treated by stathmin, poly IC and ultrapure LPS to examine the effects of different Toll-like receptor agonists

Project description:Goal of the experiment was to examine the effects of different Toll-like receptor agonists on the human astrocyte response, in termsof levels of transcripts encoding cytokines, chemokines and theirreceptors. Stathmin and poly IC are considered as agonist for TLR3, LPSas an agonist for TLR4. The manuscript we are about to submit to Journal of Immunology contains these data, and identifies stathmin, aprotein, as a novel TLR3 agonist. We all know that poly IC is, and bycomparing the transcript responses in astrocytes to either poly IC andstathmin, and observing the similarity in these responses, the experiment adds to the evidence that stathmin indeed activates a verysimilar cellular response as poly IC. The LPS-induced response,mediated by TLR4, is included as a reference, to illustrate thatanother TLR-mediated reaction produces quite something different.

2010-02-11 | E-TABM-851 | biostudies-arrayexpress

Transcriptional profile of WT, PRR and IFN-/- dendritic cells stimulated with poly IC in vivo

2013-10-01 | GSE46478 | GEO

Foxc1 reinforces quiescence in hair follicle stem cells

Project description:Quiescent stem cells are periodically activated to maintain tissue homeostasis or occasionally called into action upon injury. Molecular mechanisms that constitutively maintain stem cell identity or promote stem cell proliferation and differentiation upon activation have been extensively studied. However, it is unclear how quiescent stem cells maintain identity and reinforce quiescence when they transition from quiescence to activation. Here we show mouse hair follicle stem cell compartment induces a transcription factor, Foxc1, when activated. Importantly, deletion of Foxc1 in the activated but not quiescent stem cells compromises stem cell identity, fails to re-establish quiescence and subsequently drives premature stem cell activation.These findings uncover a dynamic, cell-intrinsic mechanism employed by hair follicle stem cells to reinforce stemness in response to activation. Poly(A)-enriched transcriptome RNA-seq on HFSCs isolated in WT and K14Cre cKO mice at anagen and early telogen stage of hair cycle.

2016-02-05 | E-GEOD-67404 | biostudies-arrayexpress

Human hair follicle microbiome

Project description:Human hair follicle microbiome

| PRJEB104876 | ENA