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Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery

ABSTRACT: Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery

PROVIDER: PRJNA748584 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15206245_1.fastq.gz	Fastqsanger.gz
	SRR15206245_2.fastq.gz	Fastqsanger.gz
	SRR15206246_1.fastq.gz	Fastqsanger.gz
	SRR15206246_2.fastq.gz	Fastqsanger.gz
	SRR15206247_1.fastq.gz	Fastqsanger.gz

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Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery

Project description:Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery

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Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery

Project description:An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room (ER) arrival, monocytes showed decreased surface molecules expression, including HLA-DR, in association to an inflammatory cytokine status and limited anti-SARS-CoV-2-specific T cell response. These alterations were mostly normalized in post-COVID-19 patients, 6 months after discharge. Acute COVID-19 monocytes transcriptome showed upregulation of anti-inflammatory, tissue repair genes such as BCL6, AREG and IL-10 and increased accessibility of chromatin. Some of these transcriptomic and epigenetic features still remained in post-COVID-19 monocytes. Importantly, a poorer expression of surface markers and low IRF1 gene transcription in circulating monocytes at ER defined a COVID-19 patients group with impaired SARS-CoV-2-specific T cell response and increased risk of requiring intensive care or dying. An early analysis of monocytes may be useful for COVID-19 patients stratification and to designing innate immunity-focused therapies.

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Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery.

Project description:An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival, monocytes showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine status and limited anti-SARS-CoV-2-specific T cell response. Most of these alterations had normalized in post-COVID-19 patients 6 months after discharge. Acute COVID-19 monocytes transcriptome showed upregulation of anti-inflammatory tissue repair genes such as BCL6, AREG and IL-10 and increased accessibility of chromatin. Some of these transcriptomic and epigenetic features still remained in post-COVID-19 monocytes. Importantly, a poorer expression of surface molecules and low IRF1 gene transcription in circulating monocytes at admission defined a COVID-19 patient group with impaired SARS-CoV-2-specific T cell response and increased risk of requiring intensive care or dying. An early analysis of monocytes may be useful for COVID-19 patient stratification and for designing innate immunity-focused therapies.

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