Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Analysis of hnRNP K interacting RNAs in myeloid KG-1a cells

ABSTRACT: Analysis of hnRNP K interacting RNAs in myeloid KG-1a cells

PROVIDER: PRJNA749749 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15249640_1.fastq.gz	Fastqsanger.gz
	SRR15249640_2.fastq.gz	Fastqsanger.gz
	SRR15249641_1.fastq.gz	Fastqsanger.gz
	SRR15249641_2.fastq.gz	Fastqsanger.gz
	SRR15249642_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Analysis of hnRNP K interacting RNAs in myeloid KG-1a cells

Project description:HNRNPK is part of the minimally deleted region (MDR) in AML del(9q). To understand the function of hnRNP K in pathogenesis of this AML subtype, we analyzed the function of hnRNP K as an RNA binding protein in myeloid cells. Co-immunoprecipitated RNAs from hnRNP K and non-related control immunoprecipitation as well as input RNA were subjected to next generation sequencing. This analysis revealed an interaction of hnRNP K with 1076 RNAs, among them many mRNAs encoding transcription factors involved in myeloid differentiation and AML pathogenesis.

2024-01-31 | GSE180831 | GEO

Transcriptomic profiling of PRMT2 wild-type and PRMT2 knockout KG-1a acute myeloid leukemia cells

Project description:PRMT2 is implicated in adhesion-dependent cytoskeletal signaling and bone marrow engraftment in acute myeloid leukemia (AML). To define the transcriptional consequences of PRMT2 loss, we performed RNA sequencing of KG-1a AML cells comparing PRMT2 wild-type cells with independent CRISPR/Cas9-generated PRMT2 knockout clones. Differential expression analysis identified a common set of genes downregulated upon PRMT2 deletion. Gene ontology and gene set enrichment analyses showed that PRMT2 loss reduced transcriptional programs associated with leukocyte activation, cell adhesion, migration, and leukocyte cell-cell adhesion. These data support a role for PRMT2 in maintaining adhesion-associated transcriptional programs in AML cells and provide a transcriptomic resource linking PRMT2-dependent signaling to leukemic cell interaction with the bone marrow microenvironment.

2026-06-15 | GSE334988 | GEO

Proteomics of exosomes derived from six human acute myeloid leukemia cell lines: KG-1a, KG-1, Kasumi-1, THP-1, U937, and HEL cells

Project description:This project includes 6 experimental groups (Group A-G) of exosomes derived from the human acute myeloid leukemia cell line KG-1a, KG-1, Kasumi-1, THP-1, U937, and HEL cells, resulting in a total of 6 Thermo RAW mass spectrometry files. LC-MS analysis was then used to identify and characterize proteins carried by leukemia cell-derived exosomes. **File Description** The uploaded "SEARCH.zip" file contains all corresponding protein, peptide, and PSM identification results for this proteomics project. All .raw files have been successfully associated with this "SEARCH.zip" file in the backend. The "null" display in the "Related File" column is a known frontend bug of the iProX platform and does not affect the validity of the data submission.

2026-05-29 | PXD079114 |

Transcriptomic profiling of PRMT2 wild-type and PRMT2 knockout KG-1a acute myeloid leukemia cells

Project description:Transcriptomic profiling of PRMT2 wild-type and PRMT2 knockout KG-1a acute myeloid leukemia cells

| PRJNA1477065 | ENA

Genome-wide Profiling of RNA Binding Targets of hnRNP H

Project description:To inform the mechanism of hnRNP H dysfunction in methamphetamine-induced dopamine release and behavior, we surveyed mRNA targets of hnRNP H via cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-seq) in striatal tissue at baseline and at 30 min post-MA (2 mg/kg, i.p.). To integrate identification of hnRNP H targets with the impact of methamphetamine on downstream gene expression and splicing, we analyzed the transcriptome of the parallel samples used in CLIP-seq.

2020-11-03 | GSE160682 | GEO

Pseudomonas sp. 1A strain:1A | isolate:1A

Project description:Pseudomonas sp. 1A strain:1A | isolate:1A Genome sequencing

| PRJNA1255296 | ENA

hnRNP A1 iCLIP

Project description:hnRNP A1 iCLIP

| PRJEB9546 | ENA

RNA sequencing of MOLM-13 and KG-1a cell lines after inhibition of S100A9 and BCL2

Project description:RNA sequencing of MOLM-13 and KG-1a cell lines after inhibition of S100A9 and BCL2

| PRJEB63353 | ENA

Enterococcus mundtii 1A strain:1A

Project description:Enterococcus mundtii 1A strain:1A Genome sequencing