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Global examination of H3K9me3 levels and PEG3 binding sites between WT and KO

ABSTRACT: Global examination of H3K9me3 levels and PEG3 binding sites between WT and KO

PROVIDER: PRJNA750512 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15291788.fastq.gz	Fastqsanger.gz
	SRR15291789.fastq.gz	Fastqsanger.gz
	SRR15291790.fastq.gz	Fastqsanger.gz
	SRR15291791.fastq.gz	Fastqsanger.gz
	SRR15291792.fastq.gz	Fastqsanger.gz

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Global examination of H3K9me3 levels and PEG3 binding sites between WT and KO

Project description:PEG3 (Paternally Expressed Gene 3) is an imprinted gene encoding a DNA-binding protein. In this study, we used MEF cells (Mouse Embryonic Fibroblast). We performed genome-wide ChIP-seq experiments profiling H3K9me3 levels as well as examine the set of genomic targets and also redefines the DNA-binding motif for the imprinted transcription factor, PEG3 in the WT and KO of Peg3. The results suggested high levels of H3K9 levels in Peg3-KO MEFs than in Peg3-WT MEFs, whereas several different genes involved several biochemical pathways seems to be have potential binding site for PEG3 protein, which tend to have a distinct profile of binding motif to its binding region. This further suggests that mammalian Peg3 may control its downstream genes in regulating several biological functions and regulate the H3K9 methylation levels.

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