Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation

ABSTRACT: Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation

PROVIDER: PRJNA762898 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15872000_1.fastq.gz	Fastqsanger.gz
	SRR15872000_2.fastq.gz	Fastqsanger.gz
	SRR15872001_1.fastq.gz	Fastqsanger.gz
	SRR15872001_2.fastq.gz	Fastqsanger.gz
	SRR15872002_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 184

Similar Datasets

Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation (METHYLATION)

Project description:Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation (METHYLATION)

| PRJNA762909 | ENA

Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation (RNA EXPRESSION)

Project description:Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation (RNA EXPRESSION)

| PRJNA762882 | ENA

Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation (METHYLATION)

Project description:The inflammatory response to surgery is essential for healing and recovery, however hyperinflammation and altered immune competence increases the risk of inflammation mediated complications. We hypothesised that, in some patients, a state of postoperative systemic inflammatory dysregulation (PSID) exists increasing the risk or infection and sepsis, and that this will be associated with, and potentially predicted by, altered patterns of genome-wide peripheral blood mononuclear cell differential DNA methylation and gene expression. In this study we utilised phenotypic extremes of postoperative plasma C-reactive protein levels to define PSID, which manifested clinically in significantly higher rates of sepsis, complications and longer hospital stays following major abdominal surgery. We identified altered DNA methylation and differential gene expression in specific immune and metabolic pathways during PSID. Our findings suggest that dysregulation results in, or from, dramatic changes in differential DNA methylation and highlights potential targets for early detection and treatment. The combination of altered DNA methylation and gene expression confirms that dysregulation is mediated at multiple levels within specific gene sets and hence, non-specific anti-inflammatory treatments such as corticosteroids alone are unlikely to represent an effective therapeutic strategy.

2021-09-17 | GSE184047 | GEO

Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation (RNA EXPRESSION)

2021-09-17 | GSE184039 | GEO

Integrated methylomic and transcriptomic characterisation of postoperative systemic inflammatory dysregulation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-17 | GSE184049 | GEO

Serum Peptidomic Profiling Reveals Systemic JAK-STAT and PI3K-Akt Dysregulation in Feline Chronic Gingivostomatitis

Project description:Feline chronic gingivostomatitis (FCGS) is a debilitating inflammatory condition characterized by severe oral pain and systemic immune dysregulation. While localized oral pathology is well-documented, the systemic peptidomic landscape and its correlation with clinical therapeutics remain poorly understood.

2026-03-03 | PXD075136 | JPOST Repository

Characterisation of DNA methylomic signatures of induced pluripotent stem cells during neuronal differentiation

Project description:Characterisation of DNA methylomic signatures of induced pluripotent stem cells during neuronal differentiation

| PRJNA663913 | ENA

Therapeutic TG2 Inhibition Reverses Systemic Multiomic Dysregulation in Celiac Disease

Project description:Background and Aims: Celiac disease (CeD) is an autoimmune disease triggered by dietary gluten in genetically predisposed individuals. Deamidation of gluten peptides by the CeD autoantigen and enzyme transglutaminase 2 (TG2) is central to the pathogenesis of CeD. Inhibition of TG2 with the specific inhibitor ZED1227 effectively prevents gluten-induced histological damage in CeD patients. Here we aimed to explore the blood DNA methylomic changes in ZED1227-treated CeD patients undergoing a gluten challenge. Results: Drug treatment revealed consistent patterns suggesting normalization of the DNA methylome indicating that ZED1227 attenuated the systemic responses to gluten challenge. Conclusions: These findings provide evidence that ZED1227 can significantly prevent the gluten-induced CeD-associated systemic changes. Clinical trial: EudraCT 2017-002241-30

2026-06-18 | GSE319777 | GEO

Therapeutic TG2 Inhibition Reverses Systemic Multiomic Dysregulation in Celiac Disease

Project description:Therapeutic TG2 Inhibition Reverses Systemic Multiomic Dysregulation in Celiac Disease

| PRJNA1425082 | ENA

Characterisation of a pathogenic non-migratory fibroblast population in systemic sclerosis skin

Project description:Characterisation of a pathogenic non-migratory fibroblast population in systemic sclerosis skin

| PRJNA1241113 | ENA