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Interacting effects of sea louse (Lepeophtheirus salmonis) infection and formalin-killed Aeromonas salmonicida in Atlantic salmon skin transcriptome

ABSTRACT: Interacting effects of sea louse (Lepeophtheirus salmonis) infection and formalin-killed Aeromonas salmonicida in Atlantic salmon skin transcriptome

PROVIDER: PRJNA773177 | ENA |

REPOSITORIES: ENA

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Interacting effects of sea louse (Lepeophtheirus salmonis) infection and formalin-killed Aeromonas salmonicida in Atlantic salmon skin transcriptome

Project description:Lepeophtheirus salmonis (sea lice) and bacterial co-infection threatens wild and farmed Atlantic salmon performance and welfare. The present microarray-based study examined the dorsal skin transcriptome response to formalin-killed Aeromonas salmonicida bacterin (ASAL) in pre-adult sea lice-infected and non-infected Atlantic salmon to fill the existing knowledge gap and aid in developing anti-co-infection strategies. To this aim, sea lice-infected and non-infected salmon were intraperitoneally injected with either phosphate-buffered saline (PBS) or ASAL (i.e., 4 injection/infection groups: PBS/no lice, PBS/lice, ASAL/no lice, and ASAL/lice). The analysis of the dorsal skin transcriptome data [Significance Analysis of Microarrays (5% FDR)] identified 345 up-regulated and 2,189 down-regulated DEPs in the comparison PBS/lice vs. PBS/no lice, and 82 up-regulated and 3 down-regulated DEPs in the comparison ASAL/lice vs. ASAL/no lice. The comparison ASAL/lice vs. PBS/lice identified 272 up-regulated and 11 down-regulated DEPs, whereas ASAL/no lice vs. PBS/no lice revealed 27 up-regulated DEPs. The skin transcriptome differences between the co-stimulated salmon (i.e., ASAL/lice) and PBS/no lice salmon accounted for 1,878 up-regulated and 3,120 down-regulated DEPs.

2022-02-28 | GSE186292 | GEO

Responses to ectoparasite salmon louse (Lepeophtheirus salmonis) in Atlantic salmon

Project description:This SuperSeries is composed of the following subset Series: GSE26981: Responses to ectoparasite salmon louse (Lepeophtheirus salmonis) in skin of Atlantic salmon GSE26984: Responses to ectoparasite salmon louse (Lepeophtheirus salmonis) in spleen of Atlantic salmon Refer to individual Series

2011-02-03 | E-GEOD-27013 | biostudies-arrayexpress

Lepeophtheirus salmonis

Project description:Lepeophtheirus salmonis (salmon louse) overview

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RNAi knock down of maternal yolk associated protein (LsYAP) in the salmon louse Lepeophtheirus salmonis

Project description:Characterisation of the maternal yolk associated protein (LsYAP) and establishment of systemic RNA interference in the salmon louse (Lepeophtheirus salmonis) (Crustacea, Copepoda)

2009-04-21 | E-TABM-685 | biostudies-arrayexpress

Lepeophtheirus salmonis

Project description:Lepeophtheirus salmonis Raw sequence reads

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Transcriptomic responses of copepodid sea lice (Lepeophtheirus salmonis) exposed to cypermethrin (Betamax®)

Project description:This study investigates transcriptomic responses of Atlantic salmon lice, Lepeophtheirus salmonis exposed to cypermethrin, a commonly used antiparasitic agent used in aquaculture. Copepodid L. salmonis were exposed to cypermethrin (Betamax®) at a concentration of 1.0ppb

2016-08-08 | GSE76555 | GEO

Differentiating size-dependent responses of juvenile pink salmon (Oncorhynchus gorbuscha) to sea lice (Lepeophtheirus salmonis) infections

Project description:Salmon infected with an ectoparasitic marine copepod, the salmon louse Lepeophtheirus salmonis, incur a wide variety of consequences depending upon host sensitivity. Juvenile pink salmon (Oncorhynchus gorbuscha) migrate from natal freshwater systems to the ocean at a young age relative to other Pacific salmon, and require rapid development of appropriate defences against marine pathogens. We analyzed the early transcriptomic responses of naïve juvenile pink salmon of sizes 0.3g (no scales), 0.7g (mid-scale development) and 2.4g (scales fully developed) to a low-level laboratory exposure with early moult stage L. salmonis. All infected size groups exhibited unique transcriptional profiles. Inflammation and inhibition of cell proliferation was identified in the smallest size class (0.3g), while increased glucose absorption and retention was identified in the middle size class (0.7g). Tissue-remodelling genes were also up-regulated in both the 0.3g and 0.7g size groups. Profiles of the 2.4g size class indicated cell-mediated immunity and possibly parasite-induced growth augmentation. Understanding a size-based threshold of resistance to L. salmonis is important for fisheries management. This work characterizes molecular responses reflecting the gradual development of innate immunity to L. salmonis between the susceptible (0.3g) and refractory (2.4g) pink salmon size classes.

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Sex-Biased Gene Expression and Sequence Conservation in Pacific and Atlantic Salmon Lice (Lepeophtheirus salmonis)

Project description:This study investigates sex-biased gene expression between populations of Atlantic and Pacific salmon lice, Lepeophtheirus salmonis. Two Atlantic L. salmonis populations were previously used for an array study (GSE56024) while a third dataset using Pacific L. salmonis was novel. Using all three populations, a consensus-based, meta-analysis approach was used to identify sex-biased and sex-specific genes.

2016-06-01 | GSE73734 | GEO

Institute of Aquaculture Lepeophtheirus salmonis constitutive gene expression analysis

Project description:Caligid copepods, also called sea lice, are common ectoparasites of wild and farmed marine fish. The salmon louse Lepeophtheirus salmonis (KrM-xyer, 1837) has emerged as a serious problem for salmon farming in the Northern hemisphere. The annual cost of sea lice to the global salmon mariculture industry has been estimated at M-^@300 million, of which the majority accounts for the cost of chemically treating the farmed salmon. The treatments available for salmonids with sea lice infestation have been limited with a large scale reliance on single products and the use of antiparasitics with similar modes of action, which when used over a long period of time can enhance the selection pressure for reduced sensitivity. Two L. salmonis laboratory strains, established from field isolates and differing in susceptibility to emamectin benzoate (EMB) were studied using a custom sea louse 15K oligonucleotide microarray and RT-qPCR. The aim of the present study was to identify differential expression of transcripts between these two strains to identify potential constitutive gene expression changes associated with reduced susceptibility to EMB. Adult male salmon lice were sampled without exposure to antiparasitic agents for the purpose of studying gene expression from unchallenged individuals. In this study changes in expression of Glutamate-gated Chloride channel (GluCl) subunits, considered the major target site for avermectin (AVM) drugs in invertebrates, was not observed, but expression changes were seen for alternative ligand-gated ion channel (LGIC) subunits that form an ion channels shown to interact with AVMs in vertebrates, but which is not traditionally considered to be a target site for AVMs in invertebrates. We hypothesise that these LGIC subunits represent additional EMB target sites in salmon lice, and that the down-regulation of these channel subunits in this EMB-resistant strain is related to the resistance phenotype.

2013-11-06 | E-MTAB-1484 | biostudies-arrayexpress

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