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Bulk RNAseq of C1Q knockout TauP301S hippocampi

ABSTRACT: Bulk RNAseq of C1Q knockout TauP301S hippocampi

PROVIDER: PRJNA773759 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16537400.fastq.gz	Fastqsanger.gz
	SRR16537401.fastq.gz	Fastqsanger.gz
	SRR16537402.fastq.gz	Fastqsanger.gz
	SRR16537403.fastq.gz	Fastqsanger.gz
	SRR16537404.fastq.gz	Fastqsanger.gz

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Bulk RNAseq of C1Q knockout TauP301S hippocampi

Project description:The effect of C1q knockout on brain gene expression was examined in non-transgenic and TauP301S mice. Complement pathway has been shown to play an important role in neurodegenerative diseases, and in-house data show that C1QC KO protects against neurodegeneration in Alzheimer's disease (AD) model. TauP301S mice have neuroinflammation and neurodegeneration in the brain and is AD model. The most severe pathology of this disease model is in hippocampus.

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