Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Profiling of 2'-O-methylation in Leishmania amazonensis rRNA using RibOxi-seq

ABSTRACT: Profiling of 2'-O-methylation in Leishmania amazonensis rRNA using RibOxi-seq

PROVIDER: PRJNA776637 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16646690_1.fastq.gz	Fastqsanger.gz
	SRR16646690_2.fastq.gz	Fastqsanger.gz
	SRR16646691_1.fastq.gz	Fastqsanger.gz
	SRR16646691_2.fastq.gz	Fastqsanger.gz
	SRR16646692_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Profiling of 2'-O-methylation in Leishmania amazonensis rRNA using RibOxi-seq

Project description:In this study we report the complete repertoire of 2'-O-methylation sites present in the rRNA of Leishmania amazonensis rRNAs and a subset of small RNAs using RibOxi-seq.

2024-05-01 | GSE186879 | GEO

Profiling of 2'-O-methylation in Leishmania major rRNA using RibOxi-seq

Project description:In this study we profiled the complete repertoire of 2'-O-methylation sites present in the rRNA and a subset of small RNAs of Leishmania major rRNA using RibOxi-seq.

2024-05-01 | GSE186878 | GEO

Profiling of 2'-O-methylation in Leishmania donovani rRNA using RibOxi-seq

Project description:In this study we used RibOxi-seq to identify 2’-O-methylation (Nm) present on rRNAs in single nucleotide resolution.

2024-05-01 | GSE186877 | GEO

Profiling of 2'-O-methylation in Leishmania major rRNA using RibOxi-seq

Project description:Profiling of 2'-O-methylation in Leishmania major rRNA using RibOxi-seq

| PRJNA776629 | ENA

Profiling of 2'-O-methylation in Leishmania donovani rRNA using RibOxi-seq

Project description:Profiling of 2'-O-methylation in Leishmania donovani rRNA using RibOxi-seq

| PRJNA776630 | ENA

Landscape of methylation on Leishmania rRNA

Project description:We determined the methylation landscape on rRNA of Leishmania major.

2025-07-06 | PXD053706 | JPOST Repository

Leishmania amazonensis

Project description:Leishmania amazonensis Transcriptome or Gene expression

| PRJNA292915 | ENA

GENE EXPRESSION PROFILING AND MOLECULAR CHARACTERIZATION OF ANTIMONY RESISTANCE IN Leishmania amazonensis

Project description:Background: Drug resistance is a major problem in leishmaniasis chemotherapy. RNA expression profiling using DNA microarrays is a suitable approach to study simultaneous events leading to a drug-resistance phenotype. Genomic analysis has been performed primarily with Old World Leishmania species and here we investigate molecular alterations in antimony resistance in the New World species L. amazonensis. Methods/Principal Findings: We selected populations of L. amazonensis for resistance to antimony by step-wise drug pressure. Gene expression of highly resistant mutants was studied using DNA microarrays. RNA expression profiling of antimony-resistant L. amazonensis revealed the overexpression of genes involved in drug resistance including the ABC transporter MRPA and several genes related to thiol metabolism. The MRPA overexpression was validated by quantitative real-time PCR and further analysis revealed that this increased expression was correlated to gene amplification as part of extrachromosomal linear amplicons in some mutants and as part of supernumerary chromosomes in other mutants. The expression of several other genes encoding hypothetical proteins but also nucleobase and glucose transporter encoding genes were found to be modulated. Conclusions/Significance: Mechanisms classically found in Old World antimony resistant Leishmania were also highlighted in New World antimony-resistant L. amazonensis. These studies were useful to the identification of resistance molecular markers.

2011-06-11 | GSE26159 | GEO

Distinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes

Project description:To determine the modulation of gene expression of C57BL/6 and DBA/2 BMDLs in the presence of living intracellular Leishmania amazonensis amastigotes

2013-01-07 | GSE38261 | GEO

Leishmania amazonensis

Project description:GENE EXPRESSION PROFILING AND MOLECULAR CHARACTERIZATION OF ANTIMONY RESISTANCE IN Leishmania amazonensis

| PRJNA135277 | ENA