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ABSTRACT: miRNA sequencing of Hainan Black goats infected with Pasteurella multocida str.HN01

PROVIDER: PRJNA781464 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16973969.fastq.gz	Fastqsanger.gz
	SRR16973970.fastq.gz	Fastqsanger.gz
	SRR16973971.fastq.gz	Fastqsanger.gz
	SRR16973972.fastq.gz	Fastqsanger.gz
	SRR16973973.fastq.gz	Fastqsanger.gz

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Project description:miRNA-seq of Hainan Black goats infected by Pasteurella multocida HN01

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Project description:Garlic is a popular flavor enhancer in modern cuisines. Although anti-atherosclerotic, anti-proliferative, hypolipidemic and chemopreventative effects of garlic are known for a long time, the mechanisms of garlic as a dietary supplement ramain largely unknown. We used microarrays to analyze the global programme of gene expression in control (cellulose) and garlic-fed C57BL/6J mice serendipitously infected with Pasteurella multocida and identified acute phase response genes, particularly Lcn2 and Orm2, as the major players in the innate response. Also dieraty garlic suppressed pasteurella infection in C57BL/6J mice.

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Project description:We sequenced the miRNAs in the liver tissues of goats to further enrich and elucidate the miRNA expression profile in their physiological cycle. The liver tissues were procured at 5-time points from the Laiwu black goats of 1 day, 2 weeks, 4 weeks, 8 weeks, and 12 weeks of age, respectively with 5 goats per time point, for a total of 25 goats. This study identified 1255 miRNAs.

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