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Targeted DamID to understand transcription factor genomic occupancy in human foetal lung progenitor cells

ABSTRACT: Targeted DamID to understand transcription factor genomic occupancy in human foetal lung progenitor cells

PROVIDER: PRJNA784520 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17065300.fastq.gz	Fastqsanger.gz
	SRR17065301.fastq.gz	Fastqsanger.gz
	SRR17065302.fastq.gz	Fastqsanger.gz
	SRR17065303.fastq.gz	Fastqsanger.gz
	SRR17065304.fastq.gz	Fastqsanger.gz

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Targeted DamID to understand transcription factor genomic occupancy in human foetal lung progenitor cells

Project description:In order to study the genomic occupancy of transcription factors, including SOX9, ETV4 and ETV5, in human foetal lung tip progenitor cells, we have introduced Targeted DamID system via lentivirus in a human foetal lung tissue derived organoid culture (Nikolic et al., 2017). We were able to identify the corresponding TF motif enrichment and discovered a potential co-regulation function of SOX9 and ETV factors in human feotal lung progenitor cells. This study has pioneered the use of targeted DamID approach in tissue derived organoid system.

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