Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Alterations in the expression of long noncoding RNAs and mRNAs in extracellular vesicles derived from the murine heart post ischemia-reperfusion injury

ABSTRACT: Alterations in the expression of long noncoding RNAs and mRNAs in extracellular vesicles derived from the murine heart post ischemia-reperfusion injury

PROVIDER: PRJNA784962 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17074474_1.fastq.gz	Fastqsanger.gz
	SRR17074474_2.fastq.gz	Fastqsanger.gz
	SRR17074475_1.fastq.gz	Fastqsanger.gz
	SRR17074475_2.fastq.gz	Fastqsanger.gz
	SRR17074476_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Alterations in the expression of long noncoding RNAs and mRNAs in extracellular vesicles derived from the murine heart post ischemia-reperfusion injury

Project description:Extracellular vesicles (EVs) play important roles in cardiovascular diseases by delivering multiple RNA molecular, such as lncRNAs and mRNA. However, the features and functional mechanisms of the lncRNAs and mRNA in cardiac EVs during ischemia-reperfusion (IR) remains poorly understood. Therefore, we performed RNA sequencing to profile the expression feature of lncRNAs and mRNAs and predict their potential functions.

2023-01-11 | GSE189888 | GEO

Differential expression of mRNAs in the heart of ischemia-reperfusion mice

Project description:To identify the role of mRNA during myocardial ischemia-reperfusion in mice, we have employed high-throughput sequencing to detect mRNA expression. Samples were collected from the control group and the ischemia reperfusion groups , with 5 samples per group. The candidate mRNA that may affect the process of myocardial ischemia-reperfusion was screened by comparing the ischemia-reperfusion group and the control group.

2023-11-15 | GSE223343 | GEO

Expression profiling of long noncoding RNAs and mRNAs in mouse plasma

Project description:Long noncoding RNA profile in the mouse plasma after ischemia-reperfusion injury (IRI).

2015-12-31 | GSE60726 | GEO

Expression profiling of long noncoding RNAs and mRNAs in mouse plasma

Project description:Long noncoding RNA profile in the mouse plasma after ischemia-reperfusion injury (IRI). In the study presented here, we mixed the plasma from three mouse after IRI and identified the genome-wide expression level of lncRNAs.

2015-12-31 | E-GEOD-60726 | biostudies-arrayexpress

Differential expression of mRNAs in the heart of ischemia-reperfusion mice

Project description:Differential expression of mRNAs in the heart of ischemia-reperfusion mice

| PRJNA925844 | ENA

Global microRNA expression profiling of mouse livers following ischemia-reperfusion injury at different stages. [mRNA]

Project description:Hepatic ischemia reperfusion injury is a dynamic process consisting of two stages: ischemia and reperfusion, and triggers a cascade of physiological and biochemical events. Given the important role of microRNAs in regulating gene expression, we analyzed gene expression changes in mouse livers at sham control, ischemia stage, and reperfusion stage. We generated global expression profiles of microRNA and mRNA genes in mouse livers subjected to ischemia reperfusion injury at the three stages, respectively. Comparison analysis showed that reperfusion injury had a distinct expression profile whereas the ischemia sample and the sham control were clustered together. Consistently, there are 69 differentially expressed microRNAs between the reperfusion sample and the sham control whereas 28 differentially expressed microRNAs between the ischemia sample and the sham control. We further identified two modes of microRNA expression changes in ischemia reperfusion injury. Functional analysis of both the differentially expressed microRNAs in the two modes and their target mRNAs revealed that ischemia injury impaired mitochondria function, nutrient consumption, and metabolism process. In contrast, reperfusion injury led to severe tissue inflammation that is predominantly an innate-immune response in the ischemia reperfusion process. Our staged analysis of gene expression profiles provides new insights into regulatory mechanisms of microRNAs in mouse hepatic ischemia reperfusion injury.

2015-10-01 | GSE72312 | GEO

Global microRNA expression profiling of mouse livers following ischemia-reperfusion injury at different stages. [miRNA]

2015-10-01 | GSE72314 | GEO

Transcriptome profiling of mRNAs in cortex of rats with cerebral ischemia and reperfusion

Project description:We analyzed transcriptomic characteristic of motor cortex from Sprague-Dawley rats brain with cerebral ischemia and reperfusion (CIR).

2024-01-12 | GSE222704 | GEO

Effect of Celastrol on LncRNAs and mRNAs Profiles of Cerebral Ischemia-Reperfusion Injury in Transient Middle Cerebral Artery Occlusion Mice Model

Project description:Celastrol plays a significant role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that celastrol post-treatment has a protective effect on ischemic stroke, the therapeutic effect of celastrol on ischemic stroke and the underlying molecular mechanism remain unclear. In the present study, focal transient cerebral ischemia was induced by transient middle cerebral artery occlusion (tMCAO) in mice and celastrol was administered immediately after reperfusion. We performed lncRNA and mRNA analysis in the ischemic hemisphere of adult mice with celastrol post-treatment through RNA-Sequencing (RNA-Seq). A total of 50 differentially expressed lncRNAs (DE lncRNAs) and 696 differentially expressed mRNAs (DE mRNAs) were identified between the sham and tMCAO group, and a total of 544 DE lncRNAs and 324 DE mRNAs were identified between the tMCAO and tMCAO+celastrol group. Bioinformatic analysis was done on the identified deregulated genes through gene ontology (GO) analysis, KEGG pathway analysis and network analysis. Pathway analysis indicated that inflammation-related signaling pathways played vital roles in the treatment of ischemic stroke by celastrol. Our study suggests celastrol treatment can effectively reduce cerebral ischemia-reperfusion injury. The bioinformatics analysis of lnRNAs and mRNAs profiles in the ischemic hemisphere of adult mice provides a new perspective in the neuroprotective effects of celastrol, particularly with regards to ischemic stroke.

2022-05-13 | GSE202659 | GEO

Transcription profiling of rat NRVMs response to ischemia and reperfusion events using Coverslip Hypoxia

Project description:NRVMs were subjected to varying durations of ischemia or ischemia+reperfusion using coverslip hypoxia. Expression profiling was used to identify genes that are differentially regulated in either event. We used microarrays to detail the global program of gene expression underlying ischemia and reperfusion using Coverslip Hypoxia and identified distinct classes of genes regulated during these processes. Experiment Overall Design: RNA was extracted from NRVMs subjected to varying durations of ischemia or ischemia+reperfusion and hybridized to rat genome Affymetrix arrays.

2008-06-15 | E-GEOD-6701 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data