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Intrinsic cardiac adrenergic (ICA) cells contribute to LPS-induced myocardial dysfunction

ABSTRACT: Intrinsic cardiac adrenergic (ICA) cells contribute to LPS-induced myocardial dysfunction

PROVIDER: PRJNA785267 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17085671_1.fastq.gz	Fastqsanger.gz
	SRR17085671_2.fastq.gz	Fastqsanger.gz
	SRR17085672_1.fastq.gz	Fastqsanger.gz
	SRR17085672_2.fastq.gz	Fastqsanger.gz
	SRR17085673_1.fastq.gz	Fastqsanger.gz

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Intrinsic cardiac adrenergic (ICA) cells contribute to LPS-induced myocardial dysfunction

Project description:The role of ICA cells in septic cardiomyopathy is unknown. Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-α production and dysfunction by lipopolysaccharide (LPS). In ICA cells, LPS activated TLR4-MyD88/TRIF-AP-1 signaling that promoted NE biosynthesis through expression of tyrosine hydroxylase, but did not trigger TNF-α production due to impairment of p65 translocation. Our findings suggest that ICA cells may be a potential therapeutic target for septic cardiomyopathy.

2022-02-02 | GSE189964 | GEO

Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction.

Project description: Not available

| S-EPMC8789803 | biostudies-literature

Gene expression in transgenic line overexpressing Arabidopsis AT5G40830 (ICA)

Project description:To investigate the genome-wide effects of ica transgenic line overexpressing AT5G40830 (ICA) involved in the cambial activity and shoot growth, we used cDNA microarrays to establish global changes in the gene expression. We selected the uppermost 1 cm of vegetative nodes in the inflorescence stems at the sixth silique stage. These showed the most distinctive changes in phenotypes and endogenous hormone levels between ica and Col-0. Expression of 9 genes (ARR5, ARR6, ARR7, EXP1, GASA4, GASA6, PME1, PME44, AT3G49220) based on microarray analysis was quantified by real-time PCR.

2016-08-31 | GSE78134 | GEO

Oceanimonas sp. ica-29

Project description:Oceanimonas sp. ica-29 Genome sequencing

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Indole-3-carboxaldehyde (ICA) mitigates morbidity and mortality in a mouse model of Graft-versus-Host-Disease

Project description:ICA-treatment following allogeneic bone marrow transplant in mice limited GvHD pathology and GVHD mortality, augmented the integrity of the intestinal mucosal barrier, and limited production of inflammatory cytokines, but did not compromise donor T cell-mediated Graft vs. Leukemia (GvL) responses. Following protracted exposure, ICA treatment also induced donor-strain-specific tolerance of engrafted T cells. We used microarray to assess gene expression changes induced by ICA in the small intestine in animals with GvHD.

2018-03-08 | GSE111512 | GEO

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.

Project description:Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.

| PRJNA1333999 | ENA

Imidazole-4-carboxamide (ICA) effect on Oryza sativa

Project description:Fairy rings are zones of stimulated grass growth by the interaction between the fungi and the plant. In the previous research, we reported the identification of the “fairy”, ICAproduced by the fairy ring-forming fungus and the mechanism of its growth-inhibiting activity using DNA microarray. We invetigate expression profiling of rice seedlings treated with ICA for the mechanism of its growth-inhibiting activity.

2019-07-26 | GSE100899 | GEO

Islet-Intrinsic Sex Differences in Inflammatory Signaling Contribute to Autoimmune Diabetes Susceptibility

Project description:Islet-Intrinsic Sex Differences in Inflammatory Signaling Contribute to Autoimmune Diabetes Susceptibility

| PRJNA1367637 | ENA

Bacillus thuringiensis strain:Bt-ICA/UNMSM10RA

Project description:Bacillus thuringiensis strain:Bt-ICA/UNMSM10RA Genome sequencing and assembly

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Extrinsic inflammatory, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis

Project description:Multiple sclerosis (MS) is the most frequent demyelinating disease and despite significant advances in the immunotherapy, disease progression still cannot be prevented. Promotion of remyelination, an endogenous repair process, represents a promising new treatment approach. However, spontaneous remyelination frequently fails in MS lesions due to an impaired differentiation of progenitor cells into mature, myelinating oligodendrocytes. Intrinsic oligodendroglial and extrinsic inflammatory factors may contribute to this differentiation block. Therefore, we compared induced pluripotent stem cell (iPSC)-derived oligodendrocytes (hiOL) from MS patients and healthy controls as well as their response to extrinsic factors. While functional capabilities or proteome compostion of both cell types were virtually indistinguishable, we discovered that Interferon-gamma (IFNÎ³) producing immune cells significantly impaired oligodendroglial differentiation and observed no differences in the functional capabilities or the proteome. In summary, these data indicate that the oligodendroglial differentiation block is not due to intrinsic oligodendroglial factors, but rather caused by the inflammatory environment present in MS lesions. These findings may contribute to the development of remyelination promoting strategies in MS.

2020-09-04 | PXD016043 | Pride

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