Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lactate treatment regulates epigenome of mouse embryonic stem cells (mESCs)

ABSTRACT: Lactate treatment regulates epigenome of mouse embryonic stem cells (mESCs)

PROVIDER: PRJNA791242 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17288228_1.fastq.gz	Fastqsanger.gz
	SRR17288228_2.fastq.gz	Fastqsanger.gz
	SRR17288229_1.fastq.gz	Fastqsanger.gz
	SRR17288229_2.fastq.gz	Fastqsanger.gz
	SRR17288230_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

Lactate treatment regulates epigenome of mouse embryonic stem cells (mESCs)

Project description:We treated mESCs with 50mM lactate to examine its impact on mESC epigenome. Interestingly, we found that lactate supplementation stimulated H3K18 lactylation accumulation on a subset of genes, which in turn promoted transcriptional elongation. Our results indicate that lactate supplementation expands transcriptional network of mouse ESCs.

2022-02-01 | GSE192358 | GEO

Lactate treatment regulates transcriptome of mouse embryonic stem cells (mESCs)

Project description:We treated mESCs with 50mM lactate to examine its impact on mESC transcriptome. Interestingly, we found that lactate supplementation activated both germline genes and cleavage embryo genes, indicating that lactate supplementation expands transcriptional network in mouse ESCs.

2022-02-01 | GSE191252 | GEO

Lactate treatment regulates transcriptome of mouse embryonic stem cells (mESCs)

Project description:Lactate treatment regulates transcriptome of mouse embryonic stem cells (mESCs)

| PRJNA790759 | ENA

Mdivi-1 treatment regulates mouse ESC epigenome

Project description:We treated mouse embryonic stem cells (ESCs) with Mdivi-1 and exmained changes of ESC epigenome.

2023-05-05 | GSE221886 | GEO

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Project description:SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

| PRJNA449119 | ENA

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [ChIP-seq]

Project description:The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in establishing the correct DNA methylome, invasion of H3K4me3 and H3K27me3 into former H3K36me3 territories and aberrant acquisition of H3K4me3 at imprinting control regions instead of DNA methylation. Importantly, maternal depletion of SETD2 results in oocyte maturation defects and subsequent one-cell arrest after fertilization. The preimplantation arrest is mainly due to a maternal cytosolic defect, since it can be largely rescued by normal oocyte cytosol. However, chromatin defects, including aberrant imprinting, persist in these embryos, leading to embryonic lethality after implantation. Thus, these data identify SETD2 as a crucial player in establishing the maternal epigenome that in turn controls embryonic development.

2019-05-01 | GSE112834 | GEO