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A molecular architecture of the vagal interoceptive system

ABSTRACT: A molecular architecture of the vagal interoceptive system

PROVIDER: PRJNA794066 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17423674.fastq.gz	Fastqsanger.gz
	SRR17423675.fastq.gz	Fastqsanger.gz
	SRR17423676.fastq.gz	Fastqsanger.gz
	SRR17423677.fastq.gz	Fastqsanger.gz
	SRR17423678.fastq.gz	Fastqsanger.gz

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A molecular architecture of the vagal interoceptive system

Project description:Interoception, the ability to timely and precisely sense changes inside the body, is critical for survival. Vagal sensory neurons (VSNs) form an important body-to-brain axis, navigating along body’s rostral-caudal axis to their target organs and dive across organ’s surface-lumen axis into appropriate tissue layers to sense stimuli with various physical properties. The brain can discriminate numerous body signals through VSNs, yet the underlying molecular coding strategy remains poorly understood. Here we show that VSNs code visceral organ, tissue layer, and stimulus modality, three key features of an interoceptive signal, in different dimensions. Large-scale single-cell profiling of VSNs from seven major organs, including the lung, heart, stomach, esophagus, duodenum, pancreas, and transverse colon, using multiplexed projection-barcodes reveals a ‘visceral organ’ dimension composed of differentially expressed gene modules coding VSN target organs along body’s rostral-caudal axis. Surprisingly, we discover another ‘tissue layer’ dimension with gene modules coding VSN ending locations along organ’s surface-lumen axis. The three independent feature-coding dimensions together specify many parallel VSN pathways in a combinatorial fashion and facilitate complex VSN projection in the brainstem. Our study thus highlights a novel multidimensional coding architecture of the mammalian vagal interoceptive system for effective signal communication.

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