A multidimensional coding architecture of the vagal interoceptive system.

ABSTRACT: Interoception, the ability to timely and precisely sense changes inside the body, is critical for survival^1-4. Vagal sensory neurons (VSNs) form an important body-to-brain connection, navigating visceral organs along the rostral-caudal axis of the body and crossing the surface-lumen axis of organs into appropriate tissue layers^5,6. The brain can discriminate numerous body signals through VSNs, but the underlying coding strategy remains poorly understood. Here we show that VSNs code visceral organ, tissue layer and stimulus modality-three key features of an interoceptive signal-in different dimensions. Large-scale single-cell profiling of VSNs from seven major organs in mice using multiplexed projection barcodes reveals a 'visceral organ' dimension composed of differen

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC8967724 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature