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The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells

ABSTRACT: The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells

PROVIDER: PRJNA795497 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17491500_1.fastq.gz	Fastqsanger.gz
	SRR17491500_2.fastq.gz	Fastqsanger.gz
	SRR17491501_1.fastq.gz	Fastqsanger.gz
	SRR17491501_2.fastq.gz	Fastqsanger.gz
	SRR17491502_1.fastq.gz	Fastqsanger.gz

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The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells [RNA-seq]

Project description:Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, an irreversible EGFR-TKI, are important treatments for non-small cell lung cancer with EGFR-TKI sensitizing or EGFR T790M resistance mutations. Whilst patients treated with osimertinib show clinical benefit, disease progression and drug resistance are common. Emergence of de novo acquired resistance from a drug tolerant persister (DTP) cell population is one mechanism proposed to explain progression on osimertinib and other targeted cancer therapies. Here we profiled osimertinib DTPs using RNA-seq, ChIP-seq, and ATAC-seq to characterize the features of these cells and performed drug screens to identify therapeutic opportunities.

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