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Human bronchial epithelial cell line Beas-2B

ABSTRACT: Human bronchial epithelial cell line Beas-2B

PROVIDER: PRJNA802137 | ENA |

REPOSITORIES: ENA

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Human bronchial epithelial cell line Beas-2B

Project description:Human bronchial epithelial cell line Beas-2B were infected with Streptococcus pneumoniae at Multiplicity of Infection (MOI) of 0.5 and 1 or treated with lipoteichonic acid (LTA) for 9 and 16 h. The mRNA profile changes upon infection shall be determined to investigate Streptococci pathogenesis.

2023-02-01 | GSE195778 | GEO

Next Generation Sequencing Analysis of miRNA profiling in Epithelial Type and Mesenchymal Type Beas-2b Cells

Project description:We reported the application of next generation sequencing technology for high-throughput profiling of miRNA expression in bronchile epithelial cell line Beas-2b with epithelial or mesenchymal mophology. By comparation the expression aboundence of known miRNAs between epithelial type and mesenchymal type Beas-2b cells, we found both upregulated and downregulated miRNAs in bronchial epithelial cells during EMT. This study provides a basic condition for further investigation of the roles of the regulated miRNAs during EMT in bronchial epithelial cells.

2018-12-26 | GSE117522 | GEO

Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

Project description:Time course transcriptomic profiling of human bronchial epithelial cell BEAS-2B exposed to a single dose of diesel and biomass ultrafine particles

2018-05-09 | E-MTAB-5157 | biostudies-arrayexpress

Comparison of gene expression profiles in chromate transformed BEAS-2B cells

Project description:We established chromate transformed cell lines by chronic exposure of normal human bronchial epithelial BEAS-2B cells to low doses of hexavalent chromium followed by anchorage-independent growth. The gene expression profiles were analyzed in the established cell lines. The gene expression profiles from six chromate transformed cell lines were remarkably similar to each other yet differed significantly from that of either control cell line or normal Beas-2B cells. A total of 409 differentially expressed genes were identified in chromate transformed cells compared to control cells.

2010-09-14 | GSE24025 | GEO

Human bronchial cells (BEAS-2B) treated with amiodarone (AM)

Project description:AAmiodarone is an antiarrhythmic drug and representatively induce pulmonary phospholipidosis. Amiodarone-induced toxicity has been a serious unpredictable side effect of the treatment and an important clinical problem. Possible causes include allergic, cytotoxic or immunologic reactions to this agent. We examined the consequences of the mechanism of amiodarone-induced pulmonary toxicity gene expression in BEAS-2B cells, huma bronchial cell line, by microarray. The expression of these genes are potential biomarker of amiodarone-induced pulmonary toxicity. Also, We provide a clue about mechanism of pulmonary toxic action by these clinical chemotherapeutic agents.

2011-01-10 | GSE20582 | GEO

Silica-exposed BEAS-2B epithelial cells

Project description:We used mass spectrometry to profile changes in metabolites, proteins, and phosphorylation in silica-exposed BEAS-2B epithelial cells.

2022-07-28 | PXD035608 |

Acute e‑cigarette aerosol condensate exposure alters the transcriptome and proteome of human bronchial epithelial BEAS‑2B cells

Project description:Electronic cigarettes (e‑cigarettes) generate aerosols by heating e‑liquids composed of propylene glycol, vegetable glycerin, nicotine, and flavoring agents. Although considered safer than conventional cigarettes, thermal decomposition of e‑liquids produces reactive carbonyls such as formaldehyde and acetaldehyde, and device hardware contributes metals and silicates. The health consequences of exposure remain incompletely understood, with evidence pointing to oxidative stress, mitochondrial dysfunction, and altered cellular responses. In this study, we investigated the acute effects of sub‑cytotoxic concentrations of e‑cigarette aerosol condensates on the human bronchial epithelial cell line BEAS‑2B. Condensates were generated from carrier liquids alone and from liquids containing nicotine and flavoring agents. We applied integrated transcriptomic and proteomic profiling, including assessment of protein modifications. Our results show that even short‑term exposure alters RNA and protein expression, disrupts protein translation and mitochondrial function, and is accompanied by irreversible protein modifications.

2026-04-06 | PXD072831 | Pride

Expression data from BEAS-2B cells

Project description:BEAS-2B cells are human bronchial epithelial cells, and often used as a in vitro model for the detection of potential pulmonary toxicity of chemicals. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes after treated with chemical substance

2017-01-10 | GSE93329 | GEO

Comparison of gene expression profiles in chromate transformed BEAS-2B cells

2010-09-14 | E-GEOD-24025 | biostudies-arrayexpress

Transcriptional and proteome profiling of human bronchial epithelial cell BEAS-2B exposed to e-cigarette aerosol condensate

Project description:We performed RNA-sequencing to evaluate the effect of acute exposure to e-cigarette aerosol condensate on lung bronchial epithelial cells by comparing the effects of carrier liquid consisting solely of propylene glycol and vegetable glycerine with e-cigarette containing nicotine and flavor. Overall design BEAS-2B cells were exposed to e-cigarette aerosol condensate generated from carrier liquid (propylene glycol and vegetable glycerine) and from e-cigarette containing 18mg/ml nicotine and Virginia tobacco flavor for 24h. Untreated cells were used as control.

2026-04-01 | GSE315683 | GEO

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