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ERK signalling orchestrates neural differentiation by promoting the polycomb repressive complex [dataset 3]

ABSTRACT: ERK signalling orchestrates neural differentiation by promoting the polycomb repressive complex [dataset 3]

PROVIDER: PRJNA807295 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18036938.fastq.gz	Fastqsanger.gz
	SRR18036939.fastq.gz	Fastqsanger.gz
	SRR18036940.fastq.gz	Fastqsanger.gz
	SRR18036941.fastq.gz	Fastqsanger.gz
	SRR18036942.fastq.gz	Fastqsanger.gz

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ERK signalling orchestrates neural differentiation by promoting the polycomb repressive complex [dataset 1]

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ERK signalling orchestrates neural differentiation by promoting the polycomb repressive complex [dataset 1]

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ERK signalling orchestrates neural differentiation by promoting the polycomb repressive complex [dataset 2]

Project description:In this experiment, Ring1b occupancy was examined in human neuromesodermal progenitors derived from embryonic stem cells (H9)

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Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors

Project description:This SuperSeries is composed of the following subset Series: GSE33653: Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq) GSE33659: Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (microarray) Refer to individual Series

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Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops

Project description:Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2) are conserved epigenetic regulators that promote transcriptional silencing. PRC1 and PRC2 converge on shared targets, catalyzing repressive histone modifications. In addition, a subset of PRC1/PRC2 targets engage in long-range interactions whose functions in gene silencing are poorly understood. Using a CRISPR screen in mouse embryonic stem cells, we discovered that the cohesin regulator PDS5A links transcriptional silencing by Polycomb and 3D genome organization. PDS5A deletion impairs cohesin unloading and results in derepression of subset of endogenous PRC1/PRC2 target genes. Importantly, derepression is not associated with loss of repressive Polycomb chromatin modifications. Instead, loss of PDS5A leads to aberrant cohesin activity, ectopic insulation sites and specific reduction of ultra-long Polycomb loops. We infer that these loops are important for robust silencing at a subset of Polycomb target genes and that maintenance of cohesin-dependent genome architecture is critical for Polycomb regulation.

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