Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome analysis of umbilical cord blood CD34+ cells of neonates delivered from SARS-CoV-2 infected and/or vaccinated mothers

ABSTRACT: Transcriptome analysis of umbilical cord blood CD34+ cells of neonates delivered from SARS-CoV-2 infected and/or vaccinated mothers

PROVIDER: PRJNA807340 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18039300_1.fastq.gz	Fastqsanger.gz
	SRR18039300_2.fastq.gz	Fastqsanger.gz
	SRR18039301_1.fastq.gz	Fastqsanger.gz
	SRR18039301_2.fastq.gz	Fastqsanger.gz
	SRR18039302_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Transcriptome analysis of umbilical cord blood CD34+ cells of neonates delivered from SARS-CoV-2 infected and/or vaccinated mothers

Project description:We report comparative transcriptome data of CD34+ cells derived from umbilical cord blood of neonates delivered from SARS-CoV-2 infected and/or vaccinated mothers or uninfected/non-vaccinated mothers.

2022-11-23 | GSE196802 | GEO

Effect of allergen sensitization on gene expression in dendritic cells from neonates of asthmatic vs control mothers

Project description:This study aims to demonstrate the link between epigenome-wide methylation aberrations at birth and genomic transcriptional changes upon allergen sensitization that occur in the neonatal dendritic cells (DC) due to maternal asthma. In an in vivo model reproducing human epidemiology findings, maternal but not paternal asthma predisposes the neonate to increased asthma risk, the effect is allergen-independent and is not genetic or environmental. Earlier we demonstrated that neonates of asthmatic mothers are born with a functional skew in splenic DCs that mediates the early-life asthma origin. These allergen-naive cells convey allergy responses to normal recipients, however minimal to no transcriptional or phenotypic changes were found to explain the functional pro-allergic alterations. In this study we profiled both allergen-naïve dendritic cells, and cells after allergen sensitization in vivo. We found that while allergen-naive DCs from asthma-at-risk neonates have minimal transcriptional change compared to controls, upon allergen sensitization, multiple genes with pre-existing epigenetic alterations show significant transcriptional change. . 24 samples from 2 batches, 3-4 replicates in each of 4 groups

2013-06-01 | E-GEOD-44678 | biostudies-arrayexpress

Effect of allergen sensitization on gene expression in dendritic cells from neonates of asthmatic vs control mothers

2013-06-01 | GSE44678 | GEO

Effect of gut microbiome transplant from neonates of particle-exposed mothers on the epigenome of dendritic cells

Project description:Effect of gut microbiome transplant from neonates of particle-exposed mothers on the epigenome of dendritic cells

| PRJNA1038745 | ENA

Umbilical cord blood methylome analysis of IVF neonates that underwent embryo culture in G5 or HTF medium

Project description:Follow-up study of IVF neonates who underwent embryo culture in G5 (Vitrolife) or HTF (Lonza) medium. Genome-wide DNA methylation profiling of IVF neonates (umbilical cord blood samples) who had undergone embryo culture in G5 medium (Vitrolife) or HTF medium (Lonza). The EPIC array was used to profile the methylome at approximately 850,000 CpG sites across the human genome.

2022-05-26 | GSE189531 | GEO

Pattern of variation in DNA methylation during pregnancy among mothers who delivered preterm in the GARBH-Ini cohort

Project description:Pattern of variation in DNA methylation during pregnancy among mothers who delivered preterm in the GARBH-Ini cohort

| PRJNA716302 | ENA

PBMC gene expression profiles from vaccinated or non-vaccinated humans challenged with influenza viruses

Project description:PBMC gene expression profiles from vaccinated or non-vaccinated humans challenged with influenza viruses

2025-08-06 | GSE253685 | GEO

Maternal regulation of biliary disease in neonates via gut microbial metabolites

Project description:<p>Maternal seeding of the microbiome in neonates promotes a long-lasting biological footprint, but how it impacts disease susceptibility in early life remains unknown. We hypothesized that feeding butyrate to pregnant mice influences the newborn’s susceptibility to biliary atresia, a severe cholangiopathy of neonates. Here, we show that butyrate administration to mothers renders newborn mice resistant to inflammation and injury of bile ducts and improves survival. The prevention of hepatic immune cell activation and survival trait is linked to fecal signatures of Bacteroidetes and Clostridia and increases glutamate/glutamine and hypoxanthine in stool metabolites of newborn mice. In human neonates with biliary atresia, the fecal microbiome signature of these bacteria is under-represented, with suppression of glutamate/glutamine and increased hypoxanthine pathways. The direct administration of butyrate or glutamine to newborn mice attenuates the disease phenotype, but only glutamine renders bile duct epithelial cells resistant to cytotoxicity by natural killer cells. Thus, maternal intake of butyrate influences the fecal microbial population and metabolites in newborn mice and the phenotypic expression of experimental biliary atresia, with glutamine promoting survival of bile duct epithelial cells.</p>

2022-01-11 | MTBLS2171 | MetaboLights

Nasal epithelium gene expression profiles from vaccinated or non-vaccinated humans challenged with influenza viruses

Project description:Nasal epithelium gene expression profiles from vaccinated or non-vaccinated humans challenged with influenza viruses

2025-07-23 | GSE253686 | GEO

Effect of gut microbiome transplant from neonates of particle-exposed mothers on the epigenome of dendritic cells

Project description:In our model the newborns of asthmatic mother mice or of mothers exposed to air pollutant particles are born with a predisposition to asthma. Gut microbiome of these pups is altered, and the transplant of the pups’ microbiome (GMT) has conferred the asthma predisposition to naïve recipients. We hypothesized that bacteria alter metabolomic profile in the gut, which polarizes the dendritic cells (DC) in the recipient by affecting epigenetic regulation in these key decision-maker cells. Here we examined DNA methylation profiles in the recipient host’s DCs to test the prediction that GMT confers alterations in DNA methylation (not seen with sterilized GMT).

2024-04-01 | GSE247470 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data