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Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

ABSTRACT: Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

PROVIDER: PRJNA808401 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18072552.fastq.gz	Fastqsanger.gz
	SRR18072553.fastq.gz	Fastqsanger.gz
	SRR18072554.fastq.gz	Fastqsanger.gz
	SRR18072555.fastq.gz	Fastqsanger.gz
	SRR18072556.fastq.gz	Fastqsanger.gz

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Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

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Epigenetic modules governing skin epidermal homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

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Molecular consequences of Dlx3 deletion by tamoxifen inducible K14 Cre in adult mouse epidermis (P42-P46) as determined by RNASeq analysis

Project description:DLX3 is a homeodomain transcription factor involved in epidermal and hair follicle differentiation. Epidermal specific deletion of DLX3 leads to IL17 related inflammation. However, the downstream signals from DLX3-deficient keratinocytes that initiates IL17 associated inflammation is not well-characterized. Therefore we performed acute Dlx3 deletion to identify the initial molecular changes causing the skin inflammatory reponse and tried to rescue the immune phenotype by STAT3 inhibitor treatment (Cryptotanshinone). In this study, we compared the epidermal and dermal transcriptome from Dlx3 wild-type (WT) and K14CreERT;DLX3 fl/fl (icKO).

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