Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenetic modules governing skin epidermal homeostasis

ABSTRACT: Epigenetic modules governing skin epidermal homeostasis

PROVIDER: PRJNA808412 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18072531.fastq.gz	Fastqsanger.gz
	SRR18072532.fastq.gz	Fastqsanger.gz
	SRR18072533.fastq.gz	Fastqsanger.gz
	SRR18072534.fastq.gz	Fastqsanger.gz
	SRR18072535.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 58

Similar Datasets

Epigenetic modules governing skin epidermal homeostasis [III]

Project description:Epigenetic modules governing skin epidermal homeostasis [III]

| PRJNA851380 | ENA

Epigenetic modules governing skin epidermal homeostasis [neonate skin epidermis]

Project description:Epigenetic modules governing skin epidermal homeostasis [neonate skin epidermis]

| PRJNA808402 | ENA

Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

Project description:Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

| PRJNA808401 | ENA

Epigenetic modules governing skin epidermal homeostasis [III]

Project description:Skin homeostasis is guided by spatiotemporal regulation of gene expression, establishing each stage of keratinocyte differentiation. The current study presents transcriptomic and chromatin profiling for the proliferating (basal) and differentiated (suprabasal) cell populations derived from neonate mice (p0-p2) skin epidermis. This multi-omic approach will enable idenitification of cell specific epidermal cross-talk central to the equlibirum.

2023-01-12 | GSE206556 | GEO

Epigenetic modules governing skin epidermal homeostasis [neonate skin epidermis]

2023-01-13 | GSE197018 | GEO

Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

2023-01-13 | GSE197019 | GEO

Epigenetic modules governing skin epidermal homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-13 | GSE197024 | GEO

Transcription Elongation Factor SPT6 Maintains Epidermal Homeostasis and Suppresses Skin Inflammation in Mice

Project description:We employed single-cell RNA sequencing (scRNA-seq) using 10x Genomics technology to investigate the impact of Supt6 epidermis-specific knockout on epidermal homeostasis in mice. The histone chaperone SPT6 is a central regulator of genomic stability. Our previous studies have shown that SPT6 promotes epidermal differentiation by regulating transcriptional elongation in human epidermal stem/progenitor cells, but its in vivo role remains unclear. Our research has discovered for the first time that the transcriptional elongation factor SPT6 regulates skin inflammation, hair follicle development, and wound healing, providing a novel therapeutic target for clinical treatment of psoriasis and related skin disorders.

2026-03-26 | GSE294435 | GEO

Peripheral serotonin regulates epidermal differentiation and dermal homeostasis

Project description:Serotonin is a neurotransmitter with key peripheral functions including regulation of vascular tone, immune responses and tissue repair. It has been shown that it is expressed in skin but its role in skin homeostasis remains unclear. We conducted transcriptomic analyses to elucidate the effects of serotonin deficiency on epidermal and dermal compartments using tryptophan hydroxylase 1 knockout mice. Our results revealed that peripheral 5-HT plays a role in epidermal differentiation, barrier integrity and homeostasis of the dermal compartment.

2026-04-10 | GSE326714 | GEO

Conditional keratinocyte-specific ADAM17 knockout in mice alters skin homeostasis

Project description:This study investigates the role of ADAM17 (a disintegrin and metalloproteinase 17) in skin homeostasis. Here, we show that mice lacking ADAM17 in keratinocytes have a normal epidermal barrier and skin architecture at birth, but develop pronounced defects in epidermal barrier integrity soon after birth and chronic dermatitis as adults. The dysregulated expression of epidermal differentiation proteins becomes evident 2 days after birth, followed by transepidermal water loss and inflammatory immune cell infiltration. Our results identify a previously unappreciated critical role of the ADAM17/EGFR signaling axis in maintaining the homeostasis of the postnatal epidermal barrier. The genome-wide effects of ADAM17 deficiency were analyzed using Agilent Whole Mouse Genome microarrays. Conditional keratinocyte-specific ADAM17 knockout mice were generated by crossing Adam17flox/flox mice with keratin-14-Cre (Krt14-Cre) transgenic mice. Adam17flox/+Krt14-Cre mice were mated with Adam17flox/flox mice to generate pups of Adam17flox/flox Krt14-Cre positive (cKO) and Krt14-Cre negative (wild-type) control littermates. The genetic background was a mix of 129Sv and C57BL/6. As material, back skin tissue biopsies (postnatal day 10) from n = 2 wild-type skin and n = 2 ADAM17 epidermal KO skin (matched WT-cKO pairs from two different litters) were used in this study.

2012-06-20 | E-GEOD-38830 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data