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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice

ABSTRACT: Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice

PROVIDER: PRJNA808606 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18076713_1.fastq.gz	Fastqsanger.gz
	SRR18076713_2.fastq.gz	Fastqsanger.gz
	SRR18076714_1.fastq.gz	Fastqsanger.gz
	SRR18076714_2.fastq.gz	Fastqsanger.gz
	SRR18076715_1.fastq.gz	Fastqsanger.gz

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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

Project description:Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

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Genome-wide analysis of exercise-responsive gene expression in murine hearts subjected to 7 days of voluntary wheel running

Project description:To undertake transcriptome-wide microarray analysis to develop a view of molecular adaptations that may underpin any benefit associated with the mild exercise regime of voluntary running Total RNA obtained from isolated whole hearts subjected to 7 days of voluntary exercise compared to sedentary control hearts (n=6/group).

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Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise.

Project description:Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume endurance/resistance exercise approach for training young mice. In the current investigation, aged mice (22-mo-old) underwent a modified version of PoWeR for 8 wk. Muscle functional, cellular, biochemical, transcriptional, and myonuclear DNA methylation analyses provide an encompassing picture of how muscle from aged mice responds to high-volume combined training. Mice run 6-8 km/d, and relative to sedentary mice, PoWeR increases plantarflexor muscle strength. The oxidative soleus of aged mice responds to PoWeR similarly to young mice in every parameter measured in previous work; this includes muscle mass, glycolytic-to-oxidative fiber type transitioning, fiber size, satellite cell frequency, and myonuclear number. The oxidative/glycolytic plantaris adapts according to fiber type, but with modest overall changes in muscle mass. Capillarity increases markedly with PoWeR in both muscles, which may be permissive for adaptability in advanced age. Comparison to published PoWeR RNA-sequencing data in young mice identified conserved regulators of adaptability across age and muscles; this includes Aldh1l1 which associates with muscle vasculature. Agrn and Samd1 gene expression is upregulated after PoWeR simultaneous with a hypomethylated promoter CpG in myonuclear DNA, which could have implications for innervation and capillarization. A promoter CpG in Rbm10 is hypomethylated by late-life exercise in myonuclei, consistent with findings in muscle tissue. PoWeR and the data herein are a resource for uncovering cellular and molecular regulators of muscle adaptation with aging.

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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice

Project description:Aged mice (22-24 mo) underwent PoWeR for 8 weeks. RRBS on myonuclei from soleus muscles (n=3 sedentary and n=3 trained) were subjected to low-input RRBS.

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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

Project description:Aged mice (22-24 mo) underwent Progressive weighted wheel running (PoWeR) for 8 weeks. RNA-seq on soleus and plantaris muscles was conducted on untrained and PoWeR trained mice. RNA from soleus and plantaris of young mice (4-6 months old) was used as a comparator (Englund et al. 2021 Function)

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Project description:Voluntary exercise reduces the risk of cancer and lowers the risk of disease recurrence. Yet the mechanisms for this protection remain to be elucidated. Here we demonstrate that exercise halves tumor growth through an exercise-dependent mobilization and intratumoral infiltration of NK cells in malignant melanoma. Using voluntary wheel running, we show that exercise prior to and during B16 tumor challenge reduced tumor growth by 67%, and this reduction was associated with increased inflammation and immune cell infiltrates, especially NK cells, in the tumors from exercising mice. Depletion of NK cells blunted the exercise-dependent reduction in tumor growth. Moreover, during exercise, NK cells were engaged through an epinephrine-dependent mobilization to the circulation and redistributed to peripheral tissues through an IL-6 dependent mechanism. This study highlights the importance of exercise-dependent immune regulation in the control of malignant melanoma Gene expression profile of melanoma tumor tissue from two groups of exercise and non-exercise mice

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Voluntary exercise suppresses tumor growth through exercise-directed recruitment and intratumoral infiltration of NK cells

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