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A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [miRNA-seq]

ABSTRACT: A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [miRNA-seq]

PROVIDER: PRJNA813863 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18271637.fastq.gz	Fastqsanger.gz
	SRR18271638.fastq.gz	Fastqsanger.gz
	SRR18271639.fastq.gz	Fastqsanger.gz
	SRR18271640.fastq.gz	Fastqsanger.gz
	SRR18271641.fastq.gz	Fastqsanger.gz

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Similar Datasets

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers

Project description:A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers

| PRJNA813858 | ENA

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [mRNA-seq]

Project description:A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [mRNA-seq]

| PRJNA813864 | ENA

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [RNA-seq and smallRNA-seq]

Project description:A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [RNA-seq and smallRNA-seq]

| PRJNA819373 | ENA

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [mRNA-seq]

Project description:Cancer cells are featured with uncontrollable activation of cell cycle and proliferation,and microRNA deficiency drives tumorigenesis. The RNA-dependent RNA polymerase (RDR) is essential for small RNA-mediated immune response in plants, but absent in vertebrates with adaptive immunity. Here we show that ectopic expression of plant RDR1 can generally inhibit the proliferation of different cancer cells. Interestingly, we find that abnormal AGO2-free microRNA isoforms with 1-nucleotide shortening at the 3’ end are widely accumulated in many tumors. RDR1 with nucleotidyltransferase activity can recognize and modify these problematic microRNAs with mononucleotides to restore their AGO2 loading efficiency, which eventually rescues microRNA deficiency and elevates microRNA expression to target cell cycle in cancer specifically. The wide antitumor effects of RDR1 can be visualized in multiple xenograft tumor models in vivo, which can be realized by adeno-associated virus-mediated delivery. Altogether, we develop a broad microRNA-mediated antitumor stratagem using the plant immune protein RDR1.

2022-03-08 | GSE198145 | GEO

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [miRNA-seq]

2022-03-08 | GSE198146 | GEO

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [RNA-seq and smallRNA-seq]

2022-03-24 | GSE199309 | GEO

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-08 | GSE198147 | GEO

Loss of HLF enables metastasis via cell-collagen interaction in solid cancers

Project description:Loss of HLF enables metastasis via cell-collagen interaction in solid cancers

| PRJNA1137349 | ENA

Novel FOXM1 Inhibitor STL001 sensitizes different human cancers to broad spectrum of anticancer drugs

Project description:Novel FOXM1 Inhibitor STL001 sensitizes different human cancers to broad spectrum of anticancer drugs

| PRJNA1085719 | ENA

UCPVax, a CD4 helper peptide vaccine induces polyfunctional Th1 cells, antibody response and epitope spreading to improve antitumor immunity [TCR-seq]

Project description:The induction of an antitumor CD4+ T helper response is essential for the efficacy of therapeutic cancer vaccines. However, few vaccines are specifically designed to target CD4+ T cells in human cancers. Here, we characterize the immune mechanisms of UCPVax, a helper peptide vaccine derived from telomerase. Ex vivo immune profiling of peripheral blood from 60 patients with advanced lung cancer reveals that UCPVax selectively activates CD4+ T cells in vivo across a broad HLA-DR restriction. The vaccine elicits a synergistic immune triad including cytokine-polyfunctional CD4+ Th1 cells, epitope spreading, and antibody response, contributing to effective tumor control. Single-cell analysis further demonstrates that UCPVax drives CD4+ T cells toward effector-memory and cytolytic differentiation. Thus, the vaccine-induced CD4+T cells trigger a broad and durable antitumor immunity. These findings highlight UCPVax as an off-the-shelf helper platform to enhance therapeutic cancer vaccine efficacy.

2025-05-13 | GSE271545 | GEO

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