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Single-cell analysis of conventional dendritic cells in an immunogenic murine melanoma model

ABSTRACT: Single-cell analysis of conventional dendritic cells in an immunogenic murine melanoma model

PROVIDER: PRJNA823542 | ENA |

REPOSITORIES: ENA

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Single-cell analysis of conventional dendritic cells in an immunogenic murine melanoma model

Project description:Single-cell RNA sequencing was used to show the heterogeneity of conventional dendritic cells in the immunigenic murine melanoma BRAFV600E Ptgs1/Ptgs2-/-. Our analysis shows that on day 6 of tumor growth, 3 distinct populations of cDC1 and 2 distinct populations of cDC2 can be found in the tumor microenvironment. The differentially expressed genes of these populations indicate a functional heterogeneity.

2023-07-13 | GSE200174 | GEO

Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis

Project description:Cholangitis mouse models were characterised by selective intrahepatic expansion of type 2 conventional dendritic cells, whereas plasmacytoid and type 1 conventional dendritic cells were not expanded. Expansion of type 2 conventional dendritic cells in human PSC lesions was confirmed by histology. Depletion studies revealed a pro-inflammatory role of type 2 conventional dendritic cells. Single-cell transcriptomics confirmed inflammatory maturation of the intrahepatic type 2 conventional dendritic cells and identified dendritic cell-derived inflammatory mediators.

2022-07-08 | E-MTAB-11821 | biostudies-arrayexpress

Genome accessibility profile at single cell level for conventional dendritic cells in human metastatic melanoma samples [snATAC-Seq]

Project description:Conventional dendritic cells (cDCs) has been shown to mediate immune checkpoint inhibitor responses in cancer patients. We used single nucleus ATAC sequencing (snATAC-seq) to analyze the epigenome of heterogeneous cDCs obtained from 14 human metastatic melanoma samples.

2025-07-30 | GSE303948 | GEO

RNA sequencing of murine conventional dendritic cell lineage 1 (cDC1) cells from mesenteric lymph nodes

Project description:A gene expression profile of the conventional dendritic cell lineage 1 from murine mesenteric lymph nodes (MLN) were constructed based on RNA-seq from nine biological biopsies. The gene expression profile was afterwards used to infer (in silico) a cDC1-specific protein-protein interactome.

2020-07-01 | GSE150549 | GEO

Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis

Project description:Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis

| PRJEB53691 | ENA

Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Project description:Activation of dendritic cells (DCs) is linked to increased glycolysis. However, the role of the mitochondrial electron transport chain (ETC) in conventional DC subset function is poorly defined. Here, we revealed that immunogenic activation elevates late oxygen consumption in cDC1s, but not cDC2s. To investigate the relevance of the ETC in DC immunogenicity, we generated mice with impaired ETC complex III function in DCs. ETC complex III impairment attenuated poised or adjuvant-triggered cDC1 activation, migration and capability to prime T cells for anti-cancer immunity, while it had a mild effect on cDC2s. Mechanistically, loss of complex III in cDC1s led to a deregulated redox and metabolite balance causing DNA hypermethylation of PU.1-binding regions. This DNA hypermethylation diminished early stimulus-induced gene expression linked to immunogenic responsiveness of cDC1s, which was rescued via ectopic expression of alternative oxidase. Our findings show how the ETC differentially regulates the immunogenic function of cDC subsets.

2026-04-14 | GSE308685 | GEO

Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells [methylation]

2026-04-14 | GSE276025 | GEO

Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells [ATAC-seq]

2026-04-14 | GSE276020 | GEO

Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells [RNA-seq]

2026-04-14 | GSE276024 | GEO

Newly Found Rat CD103− Dendritic Cells Represent a Highly Immunogenic Subpopulation of Type-2 Conventional Dendritic Cells, Corresponding to Known Dendritic Cell Subsets in Mice and Humans

Project description:Newly Found Rat CD103− Dendritic Cells Represent a Highly Immunogenic Subpopulation of Type-2 Conventional Dendritic Cells, Corresponding to Known Dendritic Cell Subsets in Mice and Humans

| PRJNA1183350 | ENA

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