Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

ABSTRACT: A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

PROVIDER: PRJNA825496 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18713600.fastq.gz	Fastqsanger.gz
	SRR18713601.fastq.gz	Fastqsanger.gz
	SRR18713602.fastq.gz	Fastqsanger.gz
	SRR18713603.fastq.gz	Fastqsanger.gz
	SRR18713604.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 178

Similar Datasets

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

Project description:We describe the cellular response to SARS-CoV-2 infections in Syrian hamsters previously immunized with mRNA, Adenovirus, and life-attenuated virus vaccines.

2022-05-16 | GSE200596 | GEO

Mucosal immune responses to live attenuated influenza vaccine in young adults

Project description:Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission of respiratory pathogens1. Live attenuated influenza vaccine (LAIV) is commonly used in children2, but its effectiveness declines with age3. This may be attributed to the gradual accumulation of homo- or hetero-subtypic immunity that blocks vaccine replication necessary to induce protective responses3, 4. Despite its demonstrable efficacy against influenza in children, correlates of protection for LAIV remain elusive5. Studying young adult volunteers we found that LAIV induced distinct, compartmentalized, antibody responses in the mucosa and blood. LAIV also induced mucosal IL-33 release in the first 8 hours post-inoculation and distinct CD8+ and cTfh T cell activation profiles. Mucosal antibodies are induced separately from blood antibodies and may provide a simple and novel correlate of protection for mucosal vaccination.

2023-10-19 | GSE230494 | GEO

Mucosal immune responses to live attenuated influenza vaccine in young adults

Project description:Mucosal immune responses to live attenuated influenza vaccine in young adults

| PRJNA961216 | ENA

Transcriptomic responses to a live-attenuated Francisella tularensis vaccine

Project description:Impact of live attenuated F. tularensis vaccine (DVC-LVS) on PBMC poly(A)-RNA expresssion in 10 subjects over time (Days 1, 2 ,7, and 14 post-vaccination) relative to pre-vaccination (Day 0).

2020-06-30 | GSE149809 | GEO

Repurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer ImmunotherapyRepurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer Immunotherapy

Project description:In this study, we show that intratumoral injections of the trivalent measles, mumps, and rubella (MMR) live attenuated viral vaccine (LAVs) modulate a potent cytotoxic T cells immune response, resulting in tumor growth inhibition and improved survival in syngeneic mouse models of hepatocellular carcinoma (HCC) and colorectal cancer (CRC).

2022-10-27 | PXD031295 | Pride

Transcriptomic responses to a live-attenuated Francisella tularensis vaccine

Project description:Transcriptomic responses to a live-attenuated Francisella tularensis vaccine

| PRJNA630207 | ENA

Transcriptional responses to oral live attenuated typhoid vaccines

Project description:Enteric fever is a major public health problem and causes numerous deaths annually. Ty21a is the only efficacious oral, live attenuated typhoid vaccine currently licensed for use, however, its mechanism of protection is poorly understood. To address this knowledge gap, we interrogated transcriptional profiles following vaccination with Ty21a and an immunogenic experimental oral live attenuated vaccine, M01ZH09, and related these findings to immunogenicity, and incubation period and disease severity following challenge with Salmonella Typhi four weeks after vaccination. Despite originating from the same parent strain (Ty2), we detected marked differences in the gene expression between both vaccines. Analysis of the transcriptome 7 days after M01ZH09 vaccination implicated transcriptional patterns associated with the cell cycle correlated significantly with humoral immunogenicity 28 days after vaccination. In contrast, significantly induced T and NK cell responses were associated with Ty21a vaccination, and integrative analysis indicated signatures reflecting amino acid metabolism with delayed onset of disease. Stimulation of PBMCs collected from participants prior to and following vaccination with the two vaccine strains in vitro confirmed the superior capacity of Ty21a to induce NK cells, validating gene expression results. These data provide insight into the effects of oral live attenuated typhoid vaccines on the human molecular immune response and underline the involvement of T cell response signatures with protection following challenge.

2017-10-12 | GSE100665 | GEO

A live attenuated SARS-CoV-2 vaccine constructed by dual inactivation of NSP16 and ORF3a

Project description:To generate a live attenuated SARS-CoV-2 vaccine through impeding or abrogation of NSP16 and ORF3a functions for sterilising immunity in host

2025-04-17 | GSE270469 | GEO

Repurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer Immunotherapy

Project description:Repurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer Immunotherapy

| PRJNA818636 | ENA

Whole blood RNAseq following live attenuated influenza vaccine in Gambian children

Project description:Whole blood RNAseq following live attenuated influenza vaccine in Gambian children

| PRJNA526839 | ENA