Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [scVDJ-seq]

ABSTRACT: Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [scVDJ-seq]

PROVIDER: PRJNA830586 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18863700.fastq.gz	Fastqsanger.gz
	SRR18863701.fastq.gz	Fastqsanger.gz
	SRR18863702.fastq.gz	Fastqsanger.gz
	SRR18863703.fastq.gz	Fastqsanger.gz
	SRR18863704.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

Project description:Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

| PRJNA830548 | ENA

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [scRNA-seq]

Project description:Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [scRNA-seq]

| PRJNA830587 | ENA

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [scVDJ-seq]

Project description:We generated LNP-mRNAs specifically encoding wildtype (WT), B.1.351 and B.1.617 SARS-CoV-2 spikes, and systematically studied their immune responses. Single cell BCR-seq and TCR-seq unveiled repertoire diversity and clonal expansions in vaccinated animals.

2022-04-25 | GSE201267 | GEO

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [bulk VDJ-seq]

Project description:Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [bulk VDJ-seq]

| PRJNA830588 | ENA

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-25 | GSE201269 | GEO

CMV-CTLs scVDJ-RNAseq

Project description:CMV-CTLs scVDJ-RNAseq

| PRJNA659230 | ENA

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2.

Project description:Lipid nanoparticle (LNP)-mRNA vaccines offer protection against COVID-19; however, multiple variant lineages caused widespread breakthrough infections. Here, we generate LNP-mRNAs specifically encoding wild-type (WT), B.1.351, and B.1.617 SARS-CoV-2 spikes, and systematically study their immune responses. All three LNP-mRNAs induced potent antibody and T cell responses in animal models; however, differences in neutralization activity have been observed between variants. All three vaccines offer potent protection against in vivo challenges of authentic viruses of WA-1, Beta, and Delta variants. Single-cell transcriptomics of WT- and variant-specific LNP-mRNA-vaccinated animals reveal a systematic landscape of immune cell populations and global gene expression. Variant-specific vaccination induces a systemic increase of reactive CD8 T cells and altered gene expression programs in B and T lymphocytes. BCR-seq and TCR-seq unveil repertoire diversity and clonal expansions in vaccinated animals. These data provide assessment of efficacy and direct systems immune profiling of variant-specific LNP-mRNA vaccination in vivo.

| S-EPMC9040489 | biostudies-literature

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [scRNA-seq]

Project description:We generated LNP-mRNAs specifically encoding wildtype (WT), B.1.351 and B.1.617 SARS-CoV-2 spikes, and systematically studied their immune responses. Single cell transcriptomics of WT- and variant-specific LNP-mRNA vaccinated animals revealed a systematic landscape of immune cell populations and global gene expression.

2022-04-25 | GSE201266 | GEO

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 [bulk VDJ-seq]

Project description:We generated LNP-mRNAs specifically encoding wildtype (WT), B.1.351 and B.1.617 SARS-CoV-2 spikes, and systematically studied their immune responses. BCR-seq and TCR-seq unveiled repertoire diversity and clonal expansions in vaccinated animals.

2022-04-25 | GSE201268 | GEO

Macrophages direct location-dependent recall of B cell memory to vaccination [scRNA-seq and scVDJ-seq]

Project description:Macrophages direct location-dependent recall of B cell memory to vaccination [scRNA-seq and scVDJ-seq]

| PRJNA1235184 | ENA