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Effect of trans-vaccenic acid(TVA) treatment on gene expression of mouse CD8+ T cells

ABSTRACT: Effect of trans-vaccenic acid(TVA) treatment on gene expression of mouse CD8+ T cells

PROVIDER: PRJNA835323 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19091853_1.fastq.gz	Fastqsanger.gz
	SRR19091853_2.fastq.gz	Fastqsanger.gz
	SRR19091854_1.fastq.gz	Fastqsanger.gz
	SRR19091854_2.fastq.gz	Fastqsanger.gz
	SRR19091855_1.fastq.gz	Fastqsanger.gz

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Effect of trans-vaccenic acid(TVA) treatment on gene expression of mouse CD8+ T cells

Project description:Effect of trans-vaccenic acid(TVA) treatment on gene expression of mouse CD8+ T cells

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Maternal trans-vaccenic acid reshapes neonatal T cell development and immune imprinting (LIME-seq)

Project description:How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. Here, we report that maternal supplementation with 25 trans-vaccenic acid (TVA) – the predominant naturally occurring trans-fatty acid in human breast milk (HBM) – promotes neonatal T cell development in mice, particularly expanding the naïve CD4+ T cell population with enhanced readiness. This implements a shift from T helper (Th)2- biased neonatal immune responses to Th1-skewing, resulting in improved adaptive immunity against viral infection and lung inflammation. Mechanistically, TVA via breastfeeding reprograms neonatal naïve CD4+ 30 T cells through a G protein coupled receptor (GPR43)-CCCTC-binding factor axis for enhanced cooperation with transcription factor TBX21, which also exhibits a longlasting immune imprinting effect. Furthermore, TVA levels in HBM from mothers of preterm infants inversely correlate with the incidence of inflammation-associated bronchopulmonary dysplasia in their preterm infants. Our findings establish the multifaceted benefits of maternal 35 nutrition and breastfeeding via TVA in promoting infant immune homeostasis and protective immunity.

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Effect of trans-vaccenic acid(TVA) treatment on gene expression of mouse CD8+ T cells

Project description:To investigate the TVA's effect on mouse CD8+ T cells in vitro, we treated activated mouse CD8+ T cells with DMSO or 20 µM TVA for 24 hours. We then performed gene expression profiling analysis using data obtained from RNA-seq.

2023-09-21 | GSE202276 | GEO

Effect of trans-vaccenic acid(TVA) treatment on gene expression of mouse CD8+ T cells

Project description:To investigate the TVA's effect on mouse CD8+ T cells in vitro, we treated activated mouse CD8+ T cells with 20 µM TVA for various timepoints (or untreated cell control) followed by kethoxal labeling of single stranded DNA (ssDNA) We then performed differential analysis of ssDNA levels following the KAS-pipe pipeline

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Trans-vaccenic acid in breastmilk primes neonatal T cell immunity

Project description:Nutrients in breastmilk can play a critical role in neonatal immune development, we employing a combination of single cell transcriptomics and epigenomic analysis to test how the milk nutrient Trans-vaccenic acid affect neonatal spleen immune cell development.

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Effect of trans-vaccenic acid(TVA) diet on 16S ribosomal RNA (rRNA) expression of mouse gut microbiome

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Dietary trans-vaccenic acid promotes anti-tumor immunity

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Trans-vaccenic acid in breastmilk primes neonatal T cell to against virus infection

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Effect of trans-vaccenic acid(TVA) diet on 16S ribosomal RNA (rRNA) expression of mouse gut microbiome

Project description:To investigate the TVA diet's effect on mouse gut microbiome, we fed C57/BL6 mice with TVA diet or CON diet for 18 days We then collected feces of the mice and performed 16S ribosomal RNA (rRNA) sequencing.

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Trans-vaccenic acid in breastmilk primes neonatal T cell immunity

Project description:Trans-vaccenic acid in breastmilk primes neonatal T cell immunity

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