Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

ABSTRACT: Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

PROVIDER: PRJNA844087 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

Project description:The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.

2023-06-20 | GSE205202 | GEO

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]

2023-06-20 | GSE205201 | GEO

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics

2023-08-31 | PXD034438 | Pride

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]

Project description:Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]

| PRJNA844092 | ENA

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

Project description:Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

| PRJNA844093 | ENA

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-20 | GSE205203 | GEO

Transcription profiling of rat blood and liver exposed to acetaminophen (APAP)

Project description:This SuperSeries is composed of the following subset Series:; GSE5593: Acetaminophen (APAP) Rat Blood Training Gene Expression Data Set; GSE5594: Acetaminophen (APAP) Rat Blood Test Gene Expression Data Set; GSE5595: Acetaminophen (APAP) Rat Liver Test Gene Expression Data Set; The Supplementary files (appended below) contain the mapping for the decoding of blinded samples. Experiment Overall Design: Refer to individual Series

2008-06-14 | E-GEOD-5652 | biostudies-arrayexpress

3'mRNA sequencing of hepatic RNA (MACE) at the time points 24h/48h after acetaminophen (APAP) (300mg/kg) administration

Project description:Hepatic RNA specimens from mice (C57BL/6) of the 4 groups (vehicle-treated at 24h/48h, n=6; acetaminophen (APAP)-treated (300mg/kg) at 24h/48h, n=7) were pooled at equal shares. Thereafter, pooled RNA underwent analysis by 3'mRNA sequencing (MACE, GenXPro, Frankurt, Germany).

2021-12-31 | GSE169071 | GEO

DIA-Based Phosphoproteomic Analysis of Kidney Tissues in Mice with Acetaminophen-Induced Kidney Injury

Project description:Acetaminophen (APAP) overdose can lead to acute kidney injury (AKI), yet its molecular mechanisms remain unclear and no effective treatments are currently available. In this study, we combined transcriptomic, proteomic, and phosphoproteomic profiling of kidneys from APAP-exposed mice to explore molecular mechanisms and potential therapeutic strategies. Ten-week-old male C57BL/6 mice were fasted overnight for 16 hours prior to APAP treatment. Acute kidney injury was induced by intraperitoneal injection of APAP overdose (300 mg/kg body weight) for 6 hours (n = 4). Control mice received an equivalent volume of PBS via intraperitoneal injection (n = 4). Kidney tissues were subsequently collected from APAP-induced kidney injury mice and PBS-injected controls.

2025-12-05 | PXD063126 | Pride

DIA-Based Proteomic Analysis of Kidney Tissues in Mice with Acetaminophen-Induced Kidney Injury

Project description:Acetaminophen (APAP) overdose can cause acute kidney injury (AKI), but its molecular mechanisms remain poorly understood and no effective treatments are currently available. In this study, we performed an integrated analysis combining transcriptomic, proteomic, and phosphoproteomic profiling of kidney tissues from APAP-treated mice to investigate the underlying molecular mechanisms and identify potential therapeutic targets. Ten-week-old male C57BL/6 mice were fasted overnight for 16 hours prior to APAP administration. AKI was induced by intraperitoneal injection of a high dose of APAP (300 mg/kg body weight) for 6 hours (n = 4), while control mice received an equivalent volume of PBS via intraperitoneal injection (n = 4). Kidney tissues were collected from both APAP-treated and control groups for downstream omics analyses.

2025-11-24 | PXD063122 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data