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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

ABSTRACT: Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

PROVIDER: PRJNA844087 | ENA |

REPOSITORIES: ENA

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

Project description:The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

Project description:Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

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Project description:Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

Project description:This SuperSeries is composed of the SubSeries listed below.

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Transcription profiling of rat blood and liver exposed to acetaminophen (APAP)

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3'mRNA sequencing of hepatic RNA (MACE) at the time points 24h/48h after acetaminophen (APAP) (300mg/kg) administration

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Project description:This study aims to investigate the role of IER2 in acetaminophen (APAP)- induced liver injury. Male C57BL/6J mice were randomized to receive a single tail vein injection of either AAV8-GFP or AAV8-Ier2. Mice were fasted overnight for 14 hours followed by intraperitoneal administration of APAP (500 mg/kg). Animals were sacrificed 8 hours post-APAP challenge, and liver tissues were collected for proteomic profiling. This study aims to characterize the proteomic changes associated with IER2 overexpression during APAP hepatotoxicity, thereby establishing a foundation for subsequent mechanistic investigations.

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