Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Time-restricted feeding mediated transcriptomic changes in the indirect flight muscle tissue in Drosophila obesity models

ABSTRACT: Time-restricted feeding mediated transcriptomic changes in the indirect flight muscle tissue in Drosophila obesity models

PROVIDER: PRJNA844399 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19511120.fastq.gz	Fastqsanger.gz
	SRR19511121.fastq.gz	Fastqsanger.gz
	SRR19511122.fastq.gz	Fastqsanger.gz
	SRR19511123.fastq.gz	Fastqsanger.gz
	SRR19511124.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Time-restricted feeding mediated transcriptomic changes in the indirect flight muscle tissue in Drosophila obesity models

Project description:The goal of the study was to investigate the mechanistic basis for Time-restricted feeding (TRF) improvement in skeletal muscle by assessing transcriptomic data of wild type (WT), WT under High-fat diet (HFD), and genetic obesity linked mutant sphingosine kinase 2 (Sk2) under ad libitum feeding (ALF) and time-restricted feeding (TRF) conditions. Next generation sequencing was used to assess the changes along a diurnal cycle in the transcriptome of Drosophila indirect flight muscle (IFM) tissue at 3-week of age under ad libitum feeding (ALF) or time-restricted feeding (TRF).

2023-01-19 | GSE205334 | GEO

Time Restricted Feeding Mitigates Obesity Through Adipocyte Thermogenesis

Project description:In obesity, misalignment of feeding time with the light/dark environment results in disruption of peripheral circadian clocks. Conversely, restricting feeding to the active period mitigates metabolic syndrome through mechanisms that remain unknown. Here we show that adipocyte thermogenesis is essential for the healthful metabolic response to time restricted feeding. Genetic enhancement of adipocyte thermogenesis through ablation of Zfp423 attenuates obesity caused by circadian mistimed high fat diet feeding through a mechanism involving creatine metabolism. Circadian control of adipocyte creatine metabolism underlies timing of diet-induced thermogenesis, and enhancement of adipocyte circadian rhythms through overexpression of the clock activator Bmal1 ameliorates metabolic complications during diet induced obesity. These findings establish creatine mediated diet-induced thermogenesis as a bioenergetic mechanism driving metabolic benefits during time-restricted feeding.

2022-10-24 | GSE181443 | GEO

Time Restricted Feeding Mitigates Obesity Through Adipocyte Thermogenesis

Project description:Time Restricted Feeding Mitigates Obesity Through Adipocyte Thermogenesis

| PRJNA752084 | ENA

Characterisation of TET function during indirect flight muscle development

Project description:Characterisation of TET function during indirect flight muscle development

| PRJNA1182650 | ENA

Characterisation of TET function during indirect flight muscle development

Project description:Enzymes of the Ten Eleven Translocation (TET) family play a key role in the regulation of gene expression in many species by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark, into 5-hydroxymethylcytosine (5hmC). Yet, TET proteins also have non-canonical modes of action beyond 5mC oxidation, notably in Drosophila, whose genomes is devoid of 5mC. Here, we assessed TET function during the development of the adult indirect flight muscles which are derived from a population of progenitors located on the larval wing imaginal discs.

2025-11-18 | GSE281163 | GEO

The effects of temporally restricted feeding on hepatic gene expression

Project description:Temporally restricted feeding is known to impact the circadian clock. This dataset shows the effects of temporally restricted feeding on the hepatic transcriptome.

2009-11-23 | GSE13060 | GEO

The effects of temporally restricted feeding on hepatic gene expression

Project description:Temporally restricted feeding is known to impact the circadian clock. This dataset shows the effects of temporally restricted feeding on the hepatic transcriptome. C57/B6 mice were entrained for two weeks to a temporally restricted feeding schedule. Food was made available only between ZT(CT)1 and ZT(CT)9. Mice were then released into constant darkness while food availability was still restricted and liver tissue was collected at the indicated timepoints on the second day in constant darkness. Total RNA was extracted and 5ug were submitted to the standard Affymetrix protocol for amplification, labeling and hybridization.

2009-11-23 | E-GEOD-13060 | biostudies-arrayexpress

Landscape of White Adipose Tissue Diurnal Rhythms during Time-restricted Feeding: Phosphorylation

Project description:Meal timing is essential in synchronization of circadian rhythms in different organ systems through clock-dependent and -independent mechanisms. Adipose tissue is a critical metabolic and endocrine organ whose circadian clock and transcriptome can be reset by meal timing. However, it remains largely unexplored how circadian rhythms in adipose tissue are organized in time-restricted feeding that intervenes meal timing. Here, we applied quantitative phospho-proteomics to characterize circadian features associated with ad libitum feeding (ALF), day/inactive phase-restricted feeding (DRF) and night/active phase-restricted feeding (NRF) in female mice.

2025-03-14 | PXD059726 | Pride

Transcriptomic changes in Drosophila tissues under Time-restricted Feeding (TRF)

Project description:Next generation sequencing was used to assess the changes along a diurnal cycle in the transcriptome of Drosophila head, periphery (entire body except the head) or the heart at 3, 5 or 7 weeks of age under ad libitum feeding (ALF) or time-restricted feeding (TRF). Next generation sequencing was used to assess the changes along a diurnal cycle in the transcriptome of Drosophila head, periphery (entire body except the head) or the heart at 3, 5 or 7 weeks of age under ad libitum feeding (ALF) or time-restricted feeding (TRF).

2015-02-18 | E-GEOD-64108 | biostudies-arrayexpress

Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats

Project description:Time-restricted eating has shown great promise for improving metabolic health in humans with obesity, but its mechanism is still not completely resolved. In this study, we investigated how time-restricted feeding (TRF) affects microglial immunometabolism using Wistar rats. High-fat diet (HFD)-fed animals became obese, but restricting food intake to the active phase reduced fat mass, reinforced the rhythmicity of the microglial transcriptome, and prevented an increase of hypothalamic microglial cell numbers. However, TRF failed to reverse HFD-induced microglial immune dysfunction and metabolic disturbances, including suppressed electron transport chain activity, increased lipid metabolism gene expression, and impaired metabolic flexibility. These findings suggest that obesity-driven microglial immunometabolic reprogramming persists despite TRF-induced weight loss and may contribute to obesogenic memory and weight regain after weight loss induced by dietary interventions.

2025-09-11 | GSE307280 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data