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Time-restricted feeding blocks kidney fibrosis and damage through diminished CD8+ T cell infiltration in obese mice

ABSTRACT: Obesity is a major risk factor for chronic kidney disease. Our lab previously showed that a short-term (2 week) time restricted feeding (TRF) intervention in an established model of diet induced obesity (DIO) reduced kidney interstitial fibrosis, increased tubular brush border integrity, and decreased CD3+ T cell numbers. There is very little known about kidney damage and T cell inflammation in obesity. Single cell RNA sequencing was used to determine transcriptomes of CD45+ cells isolated from kidneys.

ORGANISM(S): Mus musculus

PROVIDER: GSE298793 | GEO | 2026/07/16

REPOSITORIES: GEO

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