Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mouse transcriptome changes by Adrb1 mutation in PS19 mice

ABSTRACT: Mouse transcriptome changes by Adrb1 mutation in PS19 mice

PROVIDER: PRJNA846327 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19552456_1.fastq.gz	Fastqsanger.gz
	SRR19552456_2.fastq.gz	Fastqsanger.gz
	SRR19552457_1.fastq.gz	Fastqsanger.gz
	SRR19552457_2.fastq.gz	Fastqsanger.gz
	SRR19552458_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Mouse transcriptome changes by Adrb1 mutation in PS19 mice

Project description:To investigate effects of the FNSS mutation Adrb1-A187V on the gene expression profile in a mouse model of tauopathy.

2023-04-05 | GSE205558 | GEO

PS19 and PS19/C3aR KO RNAseq data

Project description:Hippocampal tissue from 9 month old WT, C3aR KO, PS19 and PS19/C3aR KO mice was processed

2018-11-08 | GSE114910 | GEO

Gene Expression of PS19 Tau transgenic mice

Project description:Expression of PS19 Tau Transgenic mice from hippocampus at different ages 3, 6, 9, and 12 months We used Affy arrays to understand the global expression profile of PS19 Tau transgenic mice

2018-08-28 | GSE89979 | GEO

p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice

Project description:Cellular senescence is characterized by irreversible cell cycle exit, acquisition of a pro-inflammatory secretory phenotype, macromolecular damage, and deregulated metabolism. Senescent cells have been implicated in many age-related diseases, including neurodegenerative disease. We have previously demonstrated that selective elimination of senescent cells, both pharmacologically and genetically, prevents neurodegenerative disease phenotypes in tau (MAPTP301S;PS19) mutant mice. Here, we show that genetically knocking out the senescence mediator p16Ink4a, a cyclin-dependent kinase inhibitor, is sufficient to attenuate senescence signatures in PS19 mice. Neurodegenerative disease phenotypes dependent on senescent cell accumulation, including neuroinflammation, phosphorylated tau burden, neurodegeneration, and cognitive impairment were blunted in the absence of p16Ink4a. Additionally, we found that PS19 mice display altered neurovascular features—including vessel dilation, increased vessel density, deregulated endothelial cell extracellular matrix, and astrocytic endfoot depolarization—which were also attenuated when p16Ink4a was knocked out. Finally, we utilized a cell-type specific knockout of p16Ink4a to show that p16Ink4a deletion in endothelial cells and microglia alone attenuates many of the same tau-dependent phenotypes as whole-body knockout of p16Ink4a. Taken together, these results indicate that onset and progression of neurodegenerative disease in PS19 mice is driven, at least in part, by p16Ink4a expressing endothelial cells and microglia.

2025-04-30 | GSE294816 | GEO

RNA sequencing of total RNA from spinal cord total lysates of the PS19 tauopathy mouse model.

Project description:RNA seqeuncing was perfomed to compare transcriptomic profiles of PS19 and control mice at four and nine months.

2021-10-23 | GSE186228 | GEO

Abundance of tRNA fragments in Tau-RNA complexes from Tau-mutant PS19 (human P301S Tau transgenic) mice hippocampus

Project description:We report the binding between tRNA fragments and Phosphorylated Tau pS396 from the hippocampus of WT controls and Tau-mutant PS19 (human P301S Tau transgenic) mice. We show tRNA fragments abundance in Tau-RNA complexes changes between the two groups. Specific tRNA fragment in the results of Real Time-qPCR were consistent with the small RNA microarray:5'tRF_GluCTC

2025-05-14 | GSE297027 | GEO

PS19 brain lysate transfection changing ER stress gene expression in Biosensor cell

Project description:To investigate whether PS19 brain lysate transfection changes ER stress gene expression in Biosensor cell

2022-12-22 | GSE217525 | GEO

Seed-competent tau monomer initiates pathology in PS19 tauopathy mice

Project description:Tau Monomer from age controlled healthy and Alzheimer's Disease LUM2_C10053 LUM2_C10054 LUM2_C10055 LUM2_C10056 LUM2_C10057 LUM2_C10058 Tau fibril from Alzheimer's Disease LUM2_630897 Tau monomer from brain of PS19 mouse at age week 1, 2, 3, 4, 5, 6 LUM1_C11496 to LUM1_C11501 Tau monomer from brain of PS19 mouse at age 1 year LUM1_705666

2022-01-06 | MSV000088651 | MassIVE

LncRNA/mRNA sequencing analysis on cerebral cortex of P301S mutant Tau transgenic mice (PS19).

Project description:Aggregation of the microtubule-associated protein, tau, can lead to neurofibrillary tangle formation in neurons and glia, the hallmark of tauopathy. The cellular damages induced by the tau overexpression and aggregation may lead to multiple pathologic features of tauopathy. However, the effect of aging on tauopathy has not been elucidated yet. Here, we conducted lncRNA/mRNA sequencing analysis on P301S mutant Tau transgenic mouse model (PS19) with different ages to track the genetic changes occurred by the aging and progression of tau overexpression.

2019-06-23 | GSE118473 | GEO

Brain transcriptome analysis of Myt1l heterozygote mutation mice

Project description:Brain transcriptome analysis of Myt1l heterozygote mutation mice

| PRJNA851803 | ENA