Project description:For the understanding intrinsic cancer cell signatures and the surrounding microenviroment, we provide single-cell 3' RNA sequencing dataon 63,689 cells from 23 CRC patients with 23 primary colorectal cancer and 10 matched normal mucosa samples. Analysis of primary colorectal cancer and normal mucosa samples depicts a comprehensive cellular landscape of colorectal cancer and potential cellular interaction, which would be a valuable resource for the development of therapeutic strategies.

2020-04-04 | GSE132465 | GEO

Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer

Project description:To investigate the dynamic changes of prostate cancer cells during neuroendocrine transdifferentiation (NEtD), we performed single-cell RNA sequencing (scRNA-seq) on longtitudinal LTL331 PDX model derived from patient samples. Analysis of the data depicts a comprehensive cellular and molecular landscape during NEtD, which would be a valuable resource for the development of strategies to delay or prevent NEtD with the potential of identifying novel prognostic and therapeutic targets

2026-09-30 | GSE297328 | GEO

Single cell 3' RNA sequencing of 6 Belgian colorectal cancer patients

Project description:For the understanding of intrinsic cancer cell signatures and the surrounding microenvironment, we provide single-cell 3’ RNA sequencing data on 27,414 cells from 6 CRC patients in core and border tumor regions, as well as in matched normal mucosa. Analysis of primary colorectal cancer and normal mucosa samples depicts a comprehensive cellular landscape of colorectal cancer and potential cellular interactions, which would be a valuable resource for the development of therapeutic strategies.

2020-04-05 | GSE144735 | GEO

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