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Single-cell transcriptional profiles of lung CD45+ immune cells from WT and Ptgs2-cKO mice

ABSTRACT: Single-cell transcriptional profiles of lung CD45+ immune cells from WT and Ptgs2-cKO mice

PROVIDER: PRJNA850941 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19752929_1.fastq.gz	Fastqsanger.gz
	SRR19752929_2.fastq.gz	Fastqsanger.gz
	SRR19752930.fastq.gz	Fastqsanger.gz

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Single-cell transcriptional profiles of lung CD45+ immune cells from WT and Ptgs2-cKO mice

Project description:To better understand the role of the COX-2-dependent lung fibroblast program in modulating the lung immune microenvironment, we generated fibroblast-targeted Ptgs2 conditional knockout (cKO) mice by crossing Pdgfra-Cre mice with Ptgs2flox/flox mice. Then we determined how Ptgs2 deficiency in CD140a+ fibroblasts alters the lung immune microenvironment by performing single-cell RNA sequencing on lung CD45+ immune cells from WT and Ptgs2-cKO mice.

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