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Differential gene expression in the colons of mice lacking neuregulin-4

ABSTRACT: Differential gene expression in the colons of mice lacking neuregulin-4

PROVIDER: PRJNA853062 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19854981.fastq.gz	Fastqsanger.gz
	SRR19854982.fastq.gz	Fastqsanger.gz
	SRR19854983.fastq.gz	Fastqsanger.gz
	SRR19854984.fastq.gz	Fastqsanger.gz
	SRR19854985.fastq.gz	Fastqsanger.gz

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Differential gene expression in the colons of mice lacking neuregulin-4

Project description:Growth factors are essential for maintenance of intestinal health at homeostasis and during inflammation. We have previously shown that exogenous treatment with the growth factor neuregulin-4 (NRG4) promotes colonocyte survival during cytokine challenge and is protective in acute models of intestinal inflammation. However, the role of endogenously expressed NRG4 in colitis is not well understood. Using NRG4-/- mice, we tested the effect of endogenous NRG4 on colitis. NRG4-/- and wild type cage-mate mice were subjected to an IL-10R neutralization model of chronic colitis. NRG4-/- mice displayed reduced inflammatory cytokine expression in the colon and a reduction in tissue CD8+ T cells at 5 weeks post induction of colitis. In unchallenged NRG4-/- mice, baseline numbers of colonic CD8+ T cell numbers were unchanged. However, there was a significant decrease in splenic CD8+ T cells. RNA sequencing from colonic homogenates showed a loss of St3gal4, a sialyltransferase involved in immune cell trafficking, in the NRG4-null animals. This loss was verified in both tissue and epithelium. The regulation of St3gal4 by NRG4 was confirmed with ex vivo epithelial colon organoid cultures from NRG4-/- mice and by induction of St3gal4 in vivo following NRG4 treatment. Together our data suggest that NRG4 regulates colonic epithelial ST3GAL4 and thus the recruitment of CD8+ T cells, but also has systemic effects on T cell maturation. These effects may combine to stimulate immune mediated inflammation during IL-10R neutralization colitis.

2023-05-23 | GSE206965 | GEO

Differential gene expression in WT mice and mice lacking PTPN2 in T cells

Project description:Differential gene expression in WT mice and mice lacking PTPN2 in T cells

| PRJEB40613 | ENA

Changes in mRNA levels in the colons of QSOX1 knockout mice compared to wild type

Project description:An analysis of mRNA levels in colons of mice lacking the disulfide catalyst QSOX1 and wildtype littermates was performed in order to comprehensively characterize the impact of QSOX1 absence on the colon. RNA was purified from 3 12 weeks old female mice and analyzed through hybridization to the Affymatrix GeneChip A-AFFY-130.

2021-10-23 | E-MTAB-11110 | biostudies-arrayexpress

Expression data from colons of mice fed psyllium fiber

Project description:Feeding dietary fiber is known to provide us many beneficial effects. We used microarrays to detail the changes of gene expression in colons of mice fed the psyllium fiber for 5 days.

2017-05-26 | GSE99292 | GEO

Differential Gene Expression in Bladders of Wild-Type Mice Compared to Mice Lacking miroRNA-29a/b1

Project description:Differential Gene Expression in Bladders of Wild-Type Mice Compared to Mice Lacking miroRNA-29a/b1

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Effect of dietary methyl donor depletion on gene expression in normal colons of ApcMin mice

Project description:Expression profiles of normal colons in ApcMin mice that were fed methyl deficient diet for 11 weeks vs controls Expression profiles of normal colons in ApcMin mice that were fed methyl deficient diet for 11 weeks vs controls fed methyl donor sufficient diets

2012-04-30 | E-GEOD-37010 | biostudies-arrayexpress

Effect of dietary methyl donor depletion on gene expression in normal colons of ApcMin mice

Project description:Expression profiles of normal colons in ApcMin mice that were fed methyl deficient diet for 11 weeks vs controls

2012-05-01 | GSE37010 | GEO

Gene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.

Project description:Lcn2 is involved in host defense against pathogens, but the function in intestinal mucosal immunity and inflammation remains largely unknown. Genetic ablation of Lcn2 results in early-onset colitis and spontaneous emergence of right-sided colonic tumors in the setting of IL-10 deficiency (Lcn2-/-;IL10-/- mice). To address whether inflammation or other mechanisms drives the site-specific tumor locations gene expression analyses in proximal versus distal colons of Lcn2-/- IL10-/- mice were performed. Differential expression between distal colon versus cecum and proximal colon samples were analyses using Affymetrix MoGene 2.0 ST arrays on formalin-fixed, paraffin-embedded tissue sections of Lcn2-/-; IL10-/-mice.

2016-03-30 | E-MTAB-4583 | biostudies-arrayexpress

effect of neuregulin on cardiocytes

Project description:Parallel treatment of adult rat primary cultured cardiocytes with neuregulin 1 beta or media only for 24 hours

2010-05-27 | E-GEOD-1094 | biostudies-arrayexpress

effect of neuregulin on cardiocytes

Project description:Parallel treatment of adult rat primary cultured cardiocytes with neuregulin 1 beta or media only for 24 hours Keywords: parallel sample

2004-12-31 | GSE1094 | GEO

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