Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hypertrophic cardiomyopathy: data of transcriptome profiling and epigenome-wide DNA methylation analysis

ABSTRACT: Hypertrophic cardiomyopathy: data of transcriptome profiling and epigenome-wide DNA methylation analysis

PROVIDER: PRJNA853188 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19859180.fastq.gz	Fastqsanger.gz
	SRR19859181.fastq.gz	Fastqsanger.gz
	SRR19859182.fastq.gz	Fastqsanger.gz
	SRR19859183.fastq.gz	Fastqsanger.gz
	SRR19859184.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 13

Similar Datasets

Hypertrophic cardiomyopathy: data of transcriptome profiling and epigenome-wide DNA methylation analysis

Project description:Hypertrophic cardiomyopathy: data of transcriptome profiling and epigenome-wide DNA methylation analysis

| PRJNA853721 | ENA

Hypertrophic cardiomyopathy: data of transcriptome profiling and epigenome-wide DNA methylation analysis

Project description:Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, and its pathogenesis is still being intensively studied to explain the reasons of significant genetic and phenotypic heterogeneity of the disease. To search for possible HCM modifier genes involved in the HCM development we first attempted to analyze gene expression profile coupled with DNA methylation profile in the hypertrophied myocardium of HCM patients; the control group consisted of patients with aortic stenosis. The transcriptome analysis identified significant differences in levels of 193 genes, most of which were underexpressed in HCM. The methylome analysis revealed 1755 nominally significant differentially methylated positions (DMPs), mostly hypomethylated in HCM. The clear differences in DNA methylation profiles between the studied groups indicate the involvement of this process in the formation of primary left ventricle hypertrophy in HCM. Based on gene ontology enrichment analysis, the majority of biological processes, overrepresented by both differentially expressed genes (DEGs) and DMP-containing genes, are involved in the regulation of locomotion and muscle structure development. The intersection of 193 DEGs and 978 DMP-containing genes pinpointed eight genes, expression of which differed between studied groups and correlated with methylation levels of the neighboring DMPs. Half of these genes (AUTS2, GIGYF1, PRRT1, and SLC17A7) were found underexpressed in HCM and involved in neurogenesis and synapse functioning. Our data suggesting the possible involvement of innervation-associated genes in HCM provide additional insights in the disease pathogenesis and expand the field of further research.

2022-12-14 | GSE207095 | GEO

Hypertrophic cardiomyopathy: data of transcriptome profiling and epigenome-wide DNA methylation analysis

2022-06-30 | GSE206978 | GEO

Human Hypertrophic Cardiomyopathy mRNA Profiling.

Project description:Cardiac biopsies were obtained from hypertrophic cardiomyopathy (HCM) patients and controls and subjected to mRNA profiling.

2024-11-12 | GSE249925 | GEO

Human Hypertrophic Cardiomyopathy mRNA Profiling.

Project description:Human Hypertrophic Cardiomyopathy mRNA Profiling.

| PRJNA1051135 | ENA

MicroRNA Profiling of Surgical Myectomy Tissue from Patients with Hypertrophic Cardiomyopathy

Project description:Using a high-throughput gene expression profiling technology, we have illuminated novel potential microRNA (miRNA) components of the molecular disease process underlying human hypertrophic cardiomyopathy (HCM). It is hoped that this will fuel future research endeavors that will eventually uncover the role miRNAs may play in the phenotypic heterogeneity of the disease, and thus, provide potential tools for identifying patients with benign versus malignant forms of the disease. Case (n = 107)-Control (n=20) study comparing the microRNA transcriptome of cardiac tissues from patients with hypertrophic cardiomyopathy to the microRNA transcriptome of control donor cardiac tissues.

2012-09-01 | E-GEOD-36946 | biostudies-arrayexpress

Transcriptome Profiling of Surgical Myectomy Tissue from Patients with Hypertrophic Cardiomyopathy

Project description:Using a high-throughput gene expression profiling technology, we have been able to develop new hypotheses regarding the molecular pathogenic mechanisms of human hypertrophic cardiomyopathy (HCM). It is hoped that these hypotheses, among others generated by this data, will fuel future research endeavors that will uncover novel biomarkers, prognostic indicators, and therapeutic targets to improve our ability to diagnose, counsel, and treat patients with this highly heterogeneous and potentially life-threatening condition. Case-control study comparing the messenger RNA transcriptome of cardiac tissues from patients with hypertrophic cardiomyopathy to the transcriptome of control donor cardiac tissues.

2012-09-01 | E-GEOD-36961 | biostudies-arrayexpress

Human Cardiac Proteome of Hypertrophic Cardiomyopathy

Project description:This study utilized TMT to characterize the cardiac proteomic differences between patients with hypertrophic cardiomyopathy and controls.

2023-04-28 | MSV000091821 | MassIVE

Comprehensive Plasma Proteomics Profiling of Hypertrophic Cardiomyopathy

Project description:The project was designed to identify plasma protein biomarkers of hypertrophic cardiomyopathy (HCM) and to specify signaling pathways.

2025-03-20 | PXD060680 | Pride

Cardiac Organoids for Modeling Hypertrophic Cardiomyopathy

Project description:Cardiac Organoids for Modeling Hypertrophic Cardiomyopathy

| PRJNA1094569 | ENA