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The RNA-seq for the kidneys injected with cisplatin and NAD precursors.

ABSTRACT: The RNA-seq for the kidneys injected with cisplatin and NAD precursors.

PROVIDER: PRJNA856281 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20001500_1.fastq.gz	Fastqsanger.gz
	SRR20001500_2.fastq.gz	Fastqsanger.gz
	SRR20001501_1.fastq.gz	Fastqsanger.gz
	SRR20001501_2.fastq.gz	Fastqsanger.gz
	SRR20001502_1.fastq.gz	Fastqsanger.gz

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The RNA-seq for the kidneys injected with cisplatin and NAD precursors.

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Project description:To clarify the effects of cisplatin (cis-diamminedichloroplatinum II, CDDP) on the gene expression profiles in renal proximal tubules, microarray analyses were carried out using total RNA samples isolated from microdissected proximal tubules and whole kidneys. The molecular events underlying acute kidney injury (AKI) in the proximal tubules of rats with cisplatin-induced nephrotoxicity were successfully clarified with 17,000 transcripts.

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Project description:The data contains the transcriptomic responses of the nephron segments (GM : glomerulus, CPT : cortical proximal tubules, and PPT : Perimedular proximal tubules) of the rat kidneys exposed to single administration of cisplatin i.v. (0, 1, 2.5, 5, 7.5 mg/kg) for 72 hours. The kidneys were fixed with formaldehyde and embedded in paraffin followed by sectioning for 8 um thickness and staining with hematoxylin and eosin staining. The nephron segments were collected using laser capture microdissection microscope for targeted RNA sequencing purposes. The whole kidneys were taken along for the comparison. This RNAseq outcomes suggest different transcriptomic responses elicited in different nephron segments upon cisplatin exposure. This dataset is part of the TransQST collection.

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