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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [I]

ABSTRACT: Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [I]

PROVIDER: PRJNA862107 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20622172.fastq.gz	Fastqsanger.gz
	SRR20622173.fastq.gz	Fastqsanger.gz
	SRR20622174.fastq.gz	Fastqsanger.gz
	SRR20622175.fastq.gz	Fastqsanger.gz
	SRR20622176.fastq.gz	Fastqsanger.gz

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Project description:Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [II]

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation.

Project description:Epithelial tissues provide front-line barriers shielding the organism from invading pathogens and harmful substances. In the airway epithelium, the combined action of multiciliated and secretory cells sustains the mucociliary escalator required for clearance of microbes and particles from the airways. Defects in components of mucociliary clearance or barrier integrity are associated with recurring infections and chronic inflammation. The timely and balanced differentiation of basal cells into mature epithelial cell subsets is therefore tightly controlled. While different growth factors regulating progenitor cell proliferation have been described, little is known about the role of metabolism in these regenerative processes. Here we show that basal cell differentiation correlates with a shift in cellular metabolism from glycolysis to fatty acid oxidation (FAO). We demonstrate both in vitro and in vivo that pharmacological and genetic impairment of FAO blocks the development of fully differentiated airway epithelial cells, compromising the repair of airway epithelia. Mechanistically, FAO links to the hexosamine biosynthesis pathway to support protein glycosylation in airway epithelial cells. Our findings unveil the metabolic network underpinning the differentiation of airway epithelia and identify novel targets for intervention to promote lung repair.

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [II]

Project description:To test the role of FAO in epithelium differentiation, we assessed genome-wide transcriptional changes in Cpt1a+/- and Cpt1a-/- primary mouse tracheal epithelial cell (mTEC) cultures analysed at the end of the expansion phase (ALI day 0) or at day 5 and 7 post air-exposure by RNA-seq.

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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [I]

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