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Expression of genes affected by ectopic expression of FOXA2 in H441 human lung adenocarcinoma cells

ABSTRACT: Expression of genes affected by ectopic expression of FOXA2 in H441 human lung adenocarcinoma cells

PROVIDER: PRJNA863629 | ENA |

REPOSITORIES: ENA

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Expression of genes affected by ectopic expression of FOXA2 in H441 human lung adenocarcinoma cells

Project description:To identify genes influenced by the ectopic expression of FOXA2 in H441 cells, we performed RNA-seq using H441 cells that are infected with lentivirus carrying rat FOXA2. We then performed gene expression profiling analysis using data obtained from RNA-seq of triplicate samples.

2025-07-01 | GSE210083 | GEO

Identification of genome-wide FOXA2-binding sites in H441 human lung adenocarcinoma cells

Project description:In order to identify FOXA2 binding sites in a genome-wide fashion, we infected H441 cells with lentivirus that carries rat Foxa2 and performed chromatin immunoprecipitation-sequencing (ChIP-seq) for FOXA2.

2025-07-01 | GSE210082 | GEO

Identification of genome-wide FOXA2-binding sites in H441 human lung adenocarcinoma cells

Project description:Identification of genome-wide FOXA2-binding sites in H441 human lung adenocarcinoma cells

| PRJNA863630 | ENA

Identify FOXA2-interacting proteins in NEPC cells

Project description:Following extensive treatment with androgen receptor (AR) pathway inhibitors, a significant number of metastatic prostate cancer develop treatment resistance, and approximately 20% of these castration-resistant prostate cancers (CRPC) transdifferentiate, at least partially, into neuroendocrine (NE) prostate cancer (NEPC).In human cancer, FOXA2 is highly expressed in most of NEPC and a small portion of CRPC patients, has been suggested as a marker of NEPC and elevated in other NE lineage cancers including SCLC. In addition, preclinical studies demonstrated that Foxa2 is required for NEPC tumor growth and metastasis in TRAMP mouse model and associated with NEPC transformation in Pten, Trp53, and Rb1 triple knockout mouse model. However, whether FOXA2 is an essential driver of NEPC, and the underlying mechanism in shaping epigenetic landscape of NEPC is largely unknown.

2025-06-12 | PXD061127 | Pride

Identify FOXA2-interacting proteins in NEPC cells

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Gene expression profile of Huh7 cells upon knock-down of FOXA2 or FOXA2-DS-S

Project description:We used siRNAs to knock-down the gene FOXA2 and the positionally-conserved ncRNA (pcRNA) FOXA2-DS-S is Huh7. We have shown that FOXA2 regulates its own expression by binding its promoter, but it can also affect the expression of the associated pcRNA FOXA2-DS-S. At the same time, we have shown that FOXA2-DS-S is necessary for the expression of the FOXA2 gene. These data suggest that the pcRNA acts locally, in cis, to regulate the expression of FOXA2. With this microarray experiment with aimed to explore further the genome-wide transcriptional effects of FOXA2-DS-S or FOXA2 knock-down.

2018-01-09 | E-MTAB-4517 | biostudies-arrayexpress

Expression data of human lung adenocarcinoma cell line H441 treated with TTF-1/NKX2-1 siRNA and TGF-beta

Project description:We determined and analyzed the effect of TTF-1/NKX2-1 on Smad3/Smad4 binding sites by ChIP-sequencing. We used expression microarrays to evaluate the effect of TTF-1/NKX2-1 siRNA on TGF-beta-induced gene expressions. H441 cells were transfected with siRNAs and treated with TGF-beta for RNA extraction and hybridization on Affymetrix microarrays. This submission represents transcriptome component of study.

2014-07-27 | E-GEOD-49675 | biostudies-arrayexpress

Differential mRNA expression analysis of H441 cells after BSGL and RSGL treatment

Project description:It has been proved RSGL contains more biological active constituents and shows stronger antitumor effect. We determined gene expression profiling in H441 cells after BSGL and RSGL treatment using RNA-seq analysis to explore the mechinasm for the stronger antitumor effects of RSGL

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Expression data of NCI-H441 cells stably expressing hsa-mir-365-2 vs empty vector

Project description:Hsa-mir-365-2 is one of the two precursors that give rise to miR-365. We discovered that miR-365 directly regulates a lung cancer and developmental gene termed thyroid transcription factor 1 (TTF-1 or NKX2-1). Hsa-mir-365-2 was transfected into NCI-H441 cells via retrovirus-mediated gene transfer. Arrays hybridized: Affymetrix GeneChip Human Gene 1.0 ST Array. A total of 4 samples were analyzed. The first two were H441 cells expressing hsa-mir-365-2 and the other two were H441 transfected with empty vector. The class comparison function (significant cutoff, 0.001) of BRB Array Tool (4.1.0 beta_3 release) was used to analyze for differentially expressed genes as a result of enforced expression of hsa-mir-365-2.

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Impact of DNA MMR activity on antiviral gene expression in H441 cells infected with influenza A virus

Project description:H441 cells lacking DNA MMR activity have reduced expression of antiviral and stress response genes during influenza A virus infection.

2019-06-28 | GSE130189 | GEO

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