Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bone formation in senile osteoporosisbone formation in senile osteoporosis

ABSTRACT: Bone formation in senile osteoporosisbone formation in senile osteoporosis

PROVIDER: PRJNA865868 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20339871.fastq.gz	Fastqsanger.gz
	SRR20339872.fastq.gz	Fastqsanger.gz
	SRR20339873.fastq.gz	Fastqsanger.gz
	SRR20339874.fastq.gz	Fastqsanger.gz
	SRR20339875.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 21

Similar Datasets

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

Project description:BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

| PRJNA865870 | ENA

Bone formation in senile osteoporosisbone formation in senile osteoporosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-03 | GSE210426 | GEO

Transcriptome Alteration Between Young and Senile Human Bone MSC

Project description:In order to uncover mechanisms of hBMSC senescence, we performed high-throughput RNA-seq using young and senile human bone MSC (hBMSC).

2023-09-20 | GSE160273 | GEO

Adipocyte-Specific TMEM41B Deficiency Enhances Bone Formation and Attenuates Osteoporosis via the YY1-Calreticulin Axis

Project description:Osteoporosis (OP) is a prevalent skeletal disorder characterized by excessive bone marrow adiposity and impaired osteogenesis. Here, we identify TMEM41B, an endoplasmic reticulum-resident protein, as a critical regulator of bone homeostasis through its actions in bone marrow adipocytes (BMAs). Adipocyte-specific deletion of TMEM41B in mice (TMEM41B AKO) significantly increased bone mass, improved trabecular and cortical bone parameters, and enhanced mechanical strength, particularly in long bones. These effects were observed in both physiological settings and pathological models, including high-fat diet-induced osteopenia and ovariectomy-induced osteoporosis. Mechanistically, TMEM41B deficiency upregulated calreticulin (Calr) expression specifically in BMAs, which promoted osteoblast differentiation and bone formation. Mechanistically, we identified the transcription factor YY1 as a key intermediary, binding to the Calr promoter to drive its expression upon TMEM41B loss. Chromatin accessibility profiling revealed enhanced osteogenic and suppressed adipogenic gene accessibility in TMEM41B AKO mice, while proteomic and transcriptomic analyses highlighted Calr as a paracrine mediator of BMAs-osteoblast crosstalk. Our findings establish TMEM41B as a novel therapeutic target for osteoporosis, with its inhibition in BMAs rescuing bone loss through the YY1-Calr axis.

2026-09-25 | GSE309211 | GEO

Adipocyte-Specific TMEM41B Deficiency Enhances Bone Formation and Attenuates Osteoporosis via the YY1-Calreticulin Axis

2026-09-30 | GSE308857 | GEO

Prmt1-mediated Otud4 methylation activates the Pabpc1–Scube3 axis to promote bone formation and ameliorate osteoporosis

Project description:Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass, deteriorated bone microarchitecture, and elevated fracture risk due to an imbalance between osteoblast-mediated formation and osteoclast-driven resorption. Although protein arginine methyltransferase 1 (Prmt1) is implicated in skeletal metabolism, its precise functional role in osteoblast biology remains elusive.

2026-08-31 | GSE344974 | GEO

Transcriptome Alteration Between Young and Senile Human Bone MSC

Project description:Transcriptome Alteration Between Young and Senile Human Bone MSC

| PRJNA672852 | ENA

scRNA-seq of bone marrow uncovers the regulatory effect of bone marrow microenvironment on osteoporosis

Project description:We have employed a single cell sequencing approach using SeekOne Genomics and Illumina Noveseq X plus platform to study the regulatory effect of bone marrow microenvironment on osteoporosis. Bone marrow is indispensable for skeletal development, bone remodeling, and the pathogenesis of osteoporosis. It serves not only as a reservoir of osteogenic and osteoclastic precursor cells, but also as a highly specialized microenvironment that directly interfaces with bone tissue. The bone marrow niche comprises diverse hematopoietic and non-hematopoietic cell populations, which collectively regulate skeletal homeostasis through extensive intercellular communication. This study reveals the heterogeneity of cellular composition and functional differences in the bone marrow niche, as well as their distinct contributions to the progression of osteoporosis.

2026-09-13 | GSE343407 | GEO

Metridium senile

Project description:Metridium senile overview

| PRJNA256218 | ENA