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Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin

ABSTRACT: Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin

PROVIDER: PRJNA873681 | ENA |

REPOSITORIES: ENA

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Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin

Project description:N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotes. Here, m6A-mRNA and lncRNA transcriptomes were profiled for HS and full-thickness normal skin (NS) tissues using human m6A-mRNA and lncRNA epitranscriptomic microarray. These data exhibited 5838 differentially m6A methylated transcripts (4706 mRNAs, 1132 lncRNAs) between HS and NS tissues. Of note, most of them (about 94%) were hypermethylated. And 3197 differentially expressed mRNAs (1466 upregulated and 1731 downregulated) were obtained by microarray. Conjoint analysis of differentially methylated and differentially expressed transcripts screened 815 transcripts (675 hyper-up, 140 hypo-down). Among them, IFNGR1 (ENST00000367739) and IL37 (ENST00000349806) are two of the most significant methylated transcripts in hyper-up and hypo-down groups. This study proposed a transcriptional regulatory network of m6A modifications on mRNA and lncRNA in human hypertrophic scar, which may bring a new clue into the development, pathogenesis, and treatment of abnormal scars.

2025-08-25 | GSE212035 | GEO

Epigenome analysis of normal skin and hypertrophic scar samples

Project description:Hypertrophic scarring (HS) is characterized by excessive extracellular matrix deposition, matrix metalloprotein gene activation, and fibroblast invasive growth. However, the methylation level of hypertrophic scarring is poorly understood. Genome wide DNA methylation profiling of normal skin and hypertrophic scar. The Illumina Infinium Methylation EPIC BeadChip (850K) was used to obtain DNA methylation profiles across approximately 853,307 CpGs in liquid based scar samples. Samples included 6 normal skin, and 6 hypertrophic scar.

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Gene Expression in Three Early Human Hypertrophic Scar Samples

Project description:The goal was to obtain expression data from the deep cones in early human hypertrophic scars to be used to confirm expression data obtained in a porcine model. Three samples of early human hypertrophic scar were obtained and processed with the Affymetrix Human GeneChip® Human Genome U133 plus 2.0. Sample demographics were Black 2, White 1; upper extremity 2, neck 1; times since injury 6.7 months and 10.8 months; and patient ages were 19 and 54.

2011-12-31 | E-GEOD-26213 | biostudies-arrayexpress

RNA-seq of human hypertrophic scar fibroblast cell treated with fkbp10 siRNA against untreated controls

Project description:human hypertrophic scar fibroblast cell treated with fkbp10 siRNA and control siRNA for 48 hours

2020-08-26 | E-MTAB-9471 | biostudies-arrayexpress

RNA-seq of human hypertrophic scar fibroblast cell treated with pcolce siRNA against untreated controls

Project description:human hypertrophic scar fibroblast cell treated with pcolce siRNA and control siRNA for 48 hours

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N6-Methyladenosine Modification Controls Circular RNA Immunity.

Project description:N6-Methyladenosine Modification Controls Circular RNA Immunity.

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Lactylome and Proteome of Human Hypertrophic Scar Tissues

Project description:Here, using a label-free quantification approach, global lactylome and proteome analyses were performed based on 4 hypertrophic scar and 4 adjacent normal skin samples.

2023-11-08 | PXD046800 |

N6-methyladenosine (m6A) modification in HEK (primary human epidermal keratinocytes)

Project description:We conducted an analysis of N6-methyladenosine (m6A) modifications in HEK (primary human epidermal keratinocytes). The primary aim of this investigation was to establish a molecular framework elucidating the role of m6A modifications in modulating the functional of keratinocytes.

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Landscape of N6-methyladenosine modification patterns in human ameloblastoma

Project description:N6-methyladenosine (m6A) is one of the most popular RNA modifications, which is widely found in messenger RNAs (mRNAs) and non-coding RNA like long no-coding RNA (lncRNAs) and circular RNA (circRNAs).In our study,we provide m6A landscape of human ameloblastoma, which expands the understanding of m6A modifications and uncovers regulation of lncRNAs and circRNAs through m6A modification in ameloblastoma.

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Microarray profiling analysis of microRNAs expression in Hypertrophic scar

Project description:Excessive repair after burn or trauma will lead to the formation of pathological scar. TGF-β1 is a powerful growth factor after wound healing. It is considered to be a key regulator of HS and various fibrotic diseases. MicroRNAs (miRNAs) can widely participate in the pathophysiological processes of various diseases by participating in post transcriptional gene regulation. At present, there is no research report on miR-361 and hypertrophic scar. This study found that miR-361 in HS is down-regulated. MiR-361 can inhibit the proliferation of HS fibroblasts and promote their apoptosis by inhibiting TGF-β1. Moreover, miR-361 can inhibit the formation of rabbit ear scar by inhibiting the expression of TGF-β1.

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