Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Exogenous Retinoic Acid on human iPSCs derived intestinal organoids

ABSTRACT: Effect of Exogenous Retinoic Acid on human iPSCs derived intestinal organoids

PROVIDER: PRJNA875061 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21349875.fastq.gz	Fastqsanger.gz
	SRR21349876.fastq.gz	Fastqsanger.gz
	SRR21349877.fastq.gz	Fastqsanger.gz
	SRR21349878.fastq.gz	Fastqsanger.gz
	SRR21349879.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 21

Similar Datasets

Effect of Exogenous Retinoic Acid on human iPSCs derived intestinal organoids

Project description:Retinoic acid promotes the in vitro growth, patterning and improves the cellular composition of human pluripotent stem-cell-derived intestinal organoids

2022-09-02 | GSE212333 | GEO

Addition of retinoic acid to kidney organoids

Project description:The addition of 5uM retinoic acid to kidney organoids at day 12 (day 7+5). This data is from the same experimental batch as data within GSE119561.

2022-03-02 | GSE165408 | GEO

Addition of retinoic acid to kidney organoids

Project description:Addition of retinoic acid to kidney organoids

| PRJNA694466 | ENA

9-cis-retinoic acid improves disease modelling in iPSC-derived liver organoids

Project description:Liver fibrosis majorly impacts global health, necessitating development of in vitro models to study disease mechanisms and develop drug therapies. Relevant models should at least include hepatocytes and hepatic stellate cells (HSCs) and ideally use three-dimensional cultures to mimic in vivo conditions. Induced pluripotent stem cells (iPSCs) allow patient-specific liver modelling, but current models based on iPSC-derived hepatocytes (iHepatocytes) and HSCs (iHSCs) still lack key functions. We developed organoids of iHepatocytes and iHSCs, and compared them to HepaRG and primary HSC organoids. RNA-sequencing analysis comparison of these cultures identified a potential role for the transcription factor RXRA in hepatocyte differentiation and HSC quiescence. Treating cells with the RXRA ligand 9-cis-retinoic acid (9CRA) promoted iHepatocyte metabolism and iHSC quiescence. In organoids, 9CRA enhanced fibrotic response to TGF-β and acetaminophen, highlighting its potential for refining iPSC-based liver fibrosis models to more faithfully replicate human drug-induced liver injury and fibrotic conditions.

2025-06-26 | GSE292959 | GEO

Gene expression changes in mouse neuroepithelial organoids in response to all-trans retinoic acid.

Project description:We describe the transcriptomic changes in neuroepithelial organoids in response to all-trans retinoic acid.

2022-10-01 | GSE214368 | GEO

PolyA RNA-seq from retinoic acid-differentiated iPSCs treated with GSK343, 5-aza, or Combo (GSK343 & 5-aza)

Project description:Analysis of steady-state mRNA levels in induced pluripotent stem cells (iPSCs) differentiated for 5 days with retinoic acid (RA) and treated for final 48 hrs with GSK343 (EZH2 inhibitor), 5-azacytidine (5-aza, DNA methyltransferase inhibitor), or their combination (Combo).

2022-11-08 | GSE207375 | GEO

Bulk RNA-seq of MilliporeSigma SCC300 human iPSC-derived colon organoids compared with undifferentiated human iPSCs and MilliporeSigma SCC321 human patient-derived colon organoids

Project description:Experiment intended to obtain expression profiles of iPSC-derived human colon organoids compared to undifferentiated human iPSCs and a patient-derived colon organoid line

2021-10-25 | E-MTAB-11026 | biostudies-arrayexpress

Regenerative landscape of intestinal organoids (scRNA-Seq)

Project description:We use RNA sequencing to describe transcriptional changes induced in intestinal organoids cultured in presence of retinoic signaling modulators

2020-05-22 | GSE147135 | GEO

9-cis-retinoic acid improves disease modelling in iPSC-derived liver organoids

Project description:9-cis-retinoic acid improves disease modelling in iPSC-derived liver organoids

| PRJNA1242238 | ENA

Regenerative landscape of intestinal organoids (bulk RNA-Seq 2)

Project description:We use RNA sequencing to describe transcriptional changes induced in intestinal organoids cultured in presence of retinoic signaling modulators

2020-05-22 | GSE147134 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data