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The influence of the transcription factor EB for BCR-induced gene expression in human Ramos B cells

ABSTRACT: The influence of the transcription factor EB for BCR-induced gene expression in human Ramos B cells

PROVIDER: PRJNA875453 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21380800.fastq.gz	Fastqsanger.gz
	SRR21380801.fastq.gz	Fastqsanger.gz
	SRR21380802.fastq.gz	Fastqsanger.gz
	SRR21380803.fastq.gz	Fastqsanger.gz
	SRR21380804.fastq.gz	Fastqsanger.gz

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The influence of the transcription factor EB for BCR-induced gene expression in human Ramos B cells

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Transcription factor EB sets the stage for fate decisions of antigen-primed B cells in the absence and presence of co-stimulation

Project description:Ligation of the B cell antigen receptor (BCR) initiates humoral immunity. However, mere BCR signaling without appropriate co-stimulation commits B cells to death rather than to differentiation into immune effector cells. How BCR activation depletes potentially autoreactive B cells while simultaneously primes for receiving rescue and differentiation signals from cognate T lymphocytes remains unknown. Here, using a mass spectrometry-based proteomic approach to identify cytosolic/nuclear shuttling elements, we uncover transcription factor EB (TFEB) as a central BCR-controlled rheostat that drives activation-induced apoptosis, and concurrently, promotes the reception of co-stimulatory rescue signals by supporting B cell migration and antigen presentation. CD40 co-stimulation prevents TFEB-driven cell death, while enhancing and prolonging TFEB’s nuclear residency, which hallmarks antigenic experience also of memory B cells. In mice, TFEB shapes the transcriptional landscape of germinal center B cells. Within the germinal center, TFEB facilitates the dark zone entry of light-zone-residing centrocytes through regulation of chemokine receptors and, by balancing the expression of Bcl-2/BH3-only family members, integrates antigen-induced apoptosis with T cell-provided CD40 survival signals. Thus, TFEB reprograms antigen-primed germinal center B cells for cell fate decisions.

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RNA-seq of Burkitt lymphoma cell lines Ramos and ST14 knockout Ramos

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Effect of expression of ZEBRA on gene expression during Ramos cells

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