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The influence of the transcription factor EB for BCR-induced gene expression in murine WEHI-231 B cells

ABSTRACT: The influence of the transcription factor EB for BCR-induced gene expression in murine WEHI-231 B cells

PROVIDER: PRJNA875456 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21380832.fastq.gz	Fastqsanger.gz
	SRR21380833.fastq.gz	Fastqsanger.gz
	SRR21380834.fastq.gz	Fastqsanger.gz
	SRR21380835.fastq.gz	Fastqsanger.gz
	SRR21380836.fastq.gz	Fastqsanger.gz

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RNA-Seq analysis of the WEHI-231-derived stable cell lines WEHI-control and WEHI-miR-148a

Project description:miRNAs regulate the expression of its targets genes by promoting mRNA degradation and translational repression. The goal of this study is to perform RNA-Seq in control or miR-148a-expressing WEHI-231 cell lines for the identification of miR-148a target genes. WEHI-control and WEHI-miR-148a cells were stimulated with anti-IgM (2 ug/ml) for 14 h. Total RNA was extracted, enriched for polyA-containing RNAs and submitted to RNA-Seq.

2016-02-22 | E-GEOD-75809 | biostudies-arrayexpress

RNA-Seq analysis of the WEHI-231-derived stable cell lines WEHI-control and WEHI-miR-148a

2016-02-22 | GSE75809 | GEO

The influence of the transcription factor EB for BCR-induced gene expression in murine WEHI-231 B cells

Project description:To investigate TFEB-dependent expression in BCR-stimulated and resting B cells, CRISPR/Cas9 knockout cell lines were established and subjected to RNA sequencing analysis

2024-06-25 | GSE212457 | GEO

Comparison of extracellular vesicles released from mouse WEHI-231 B cells under isotype or anti-CD24 antibody stimulation

Project description:WEHI-231 extracellular vesicles, regardless of stimulation, predominantely contain 5S and 5.8S rRNA. No differentially expressed transcripts were identified, but CD24 induces an overall reduction in protein coding transcripts.

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Transcriptome analysis of WEHI B lymphoma cells overexpressing individual NFATc1 proteins

Project description:In lymphocytes, NFATc1 is the most prominent NFAT transcription factor which play a crucial role in the fate and activity of peripheral T and B cells. NFATc1 is synthesized in two prominent isoforms, the inducible short isoform NFATc1/aA and the constitutively expressed long isoform NFATc1/C. Several lines of evidence suggested that both isoforms differ markedly in their function. It was speculated that NFATc1/aA supports the proliferation and survival of lymphocytes, whereas NFATc1/C should support apoptosis and anergy induction. To proof this hypothesis we established WEHI 231 B lymphoma cells that stably (over-) express either NFATc1/aA or NFATc1/C. In preliminary experiments we could should that WEHI cells overexpressing NFATc1/aA were protected against apoptosis induction, while cells overexpressing NFATc1/C should a higher apoptosis rate. Transcriptom analysis of WEHI-231 cells overexpressing either NFATc1/aA or NFATc1/C were performed, along with a control group of WEHI-231 cells overexpressing the E.coli enzyme BirA Ligase (which is also present in all target cell lines since for further molecular assays the NFATc1 proteins were expressed as chimeric protein containing C-terminal bio-tags. The experimental results obtained indicate that the both NFATc1 proteins, NFATc1/aA and NFATc1/C, differ tremendously in their transcriptional properties.

2016-07-01 | E-MTAB-4665 | biostudies-arrayexpress

The influence of the transcription factor EB for BCR-induced gene expression in human Ramos B cells

Project description:The influence of the transcription factor EB for BCR-induced gene expression in human Ramos B cells

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Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [ChIP-Seq]

Project description:Analysis of CTCF binding in Wehi-231 with TFII-I knockdown compare to Wehi-231 wt. ChIP experiment of CTCF in Wehi-231-CT and Wehi-231-shTFII-I

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Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [ChIP-Seq]

Project description:Analysis of CTCF binding in Wehi-231 with TFII-I knockdown compare to Wehi-231 wt.

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Project description:To investigate TFEB-dependent expression in BCR-stimulated and resting B cells, CRISPR/Cas9 knockout cell lines were established and subjected to RNA sequencing analysis

2024-06-25 | GSE212456 | GEO

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [gene expression]

Project description:Analysis of the effect of TFII-I depletion on gene expression Wehi-231 cell lines. Total RNA were extract from shCT and shTFII-I Wehi-231 cells.

2014-08-29 | E-GEOD-60915 | biostudies-arrayexpress

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