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Latexin regulates hematopoiesis in a sex-dependent manner by differential expression of sex chromosome-specific microRNA 98-3p and thrombospondin 1

ABSTRACT: Latexin regulates hematopoiesis in a sex-dependent manner by differential expression of sex chromosome-specific microRNA 98-3p and thrombospondin 1

PROVIDER: PRJNA880329 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21553929.fastq.gz	Fastqsanger.gz
	SRR21553930.fastq.gz	Fastqsanger.gz
	SRR21553931.fastq.gz	Fastqsanger.gz
	SRR21553932.fastq.gz	Fastqsanger.gz
	SRR21553933.fastq.gz	Fastqsanger.gz

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Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1.

Project description:Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate to all blood cell types. HSCs and their differentiated progeny show sex/gender differences. The fundamental mechanisms remain largely unexplored. We previously reported that latexin (Lxn) deletion increased HSC survival and repopulation capacity in female mice. Here, we find no differences in HSC function and hematopoiesis in Lxn knockout (Lxn-/-) male mice under physiologic and myelosuppressive conditions. We further find that Thbs1, a downstream target gene of Lxn in female HSCs, is repressed in male HSCs. Male-specific high expression of microRNA 98-3p (miR98-3p) contributes to Thbs1 suppression in male HSCs, thus abrogating the functional effect of Lxn in male HSCs and hematopoiesis. These findings uncover a regulatory mechanism involving a sex-chromosome-related microRNA and its differential control of Lxn-Thbs1 signaling in hematopoiesis and shed light on the process underlying sex dimorphism in both normal and malignant hematopoiesis.

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Latexin regulates hematopoiesis in a sex-dependent manner by differential expression of sex chromosome-specific microRNA 98-3p and thrombospondin 1

Project description:To investigate the molecular mechanism underlying gender-specific regulation of hematopoiesis by Lxn. RNA sequencing was performed on LSK cells that were isolated from male and female WT and Lxn-/- mice.

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