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Impaired dynamic X-chromosome inactivation maintenance in T lymphocytes is a feature of spontaneous lupus in female mice that is exacerbated in female-biased disease models

ABSTRACT: Impaired dynamic X-chromosome inactivation maintenance in T lymphocytes is a feature of spontaneous lupus in female mice that is exacerbated in female-biased disease models

PROVIDER: PRJNA880517 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21562305.fastq.gz	Fastqsanger.gz
	SRR21562306.fastq.gz	Fastqsanger.gz
	SRR21562307.fastq.gz	Fastqsanger.gz
	SRR21562308.fastq.gz	Fastqsanger.gz
	SRR21562309.fastq.gz	Fastqsanger.gz

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Impaired dynamic X-chromosome inactivation maintenance in T lymphocytes is a feature of spontaneous lupus in female mice that is exacerbated in female-biased disease models

Project description:The molecular basis for the female bias of systemic lupus erythematosus remains unclear. We sought to determine the fidelity of dynamic X-chromosome inactivation maintenance in the pathogenesis of murine models of spontaneous lupus, including the heavily female-biased NZM2328 model.

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Female-biased embryonic death from genomic instability-induced inflammation

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Project description:Xist ribonucleoprotein particles promote female sex-biased autoimmunity [10X multi-ome]

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Project description:Xist ribonucleoprotein particles promote female sex-biased autoimmunity [bulk ATAC-seq]

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Julidochromis species male vs. female 20100721

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Project description:Sexual dimorphism depends on sex-biased gene expression, but the contributions of microRNAs (miRNAs) have not been globally assessed. We therefore produced an extensive small RNA sequencing dataset to analyse male and female miRNA expression profiles in mouse, opossum and chicken. Our analyses uncovered numerous cases of somatic sex-biased miRNA expression, especially in the mouse heart and liver. Sex-biased expression is explained by miRNA-specific regulation, including sex-biased chromatin accessibility at promoters, rather than piggybacking of intronic miRNAs on sex-biased protein-coding genes. In mouse, but not opossum and chicken, sex bias is coordinated across tissues such that autosomal testis-biased miRNAs tend to be somatically male-biased, whereas autosomal ovary-biased miRNAs are female-biased, possibly due to broad hormonal control. In chicken, which has a Z/W sex chromosome system, expression output of genes on the Z chromosome is expected to be male-biased, since there is no global dosage compensation mechanism that restores expression in ZW females after almost all genes on the W chromosome decayed. Nevertheless, we found that the dominant liver miRNA, miR-122-5p, is Z-linked but expressed in an unbiased manner, due to the unusual retention of a W-linked copy. Another Z-linked miRNA, the male-biased miR-2954-3p, shows conserved preference for dosage-sensitive genes on the Z chromosome, based on computational and experimental data from chicken and zebra finch, and acts to equalise male-to-female expression ratios of its targets. Unexpectedly, our findings thus establish miRNA regulation as a novel gene-specific dosage compensation mechanism.

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