Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

IFN-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity

ABSTRACT: IFN-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity

PROVIDER: PRJNA890652 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

IFN-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity

Project description:Interferons (IFNs) induced early after SARS-CoV-2 infection are crucial for shaping immunity and preventing severe COVID-19. We previously demonstrated that injection of pegylated interferon-lambda1 (PEG-IFN-λ) accelerated viral clearance in COVID-19 patients. To determine if the viral decline was mediated by enhanced immunity, we assessed in vivo responses to PEG-IFN-λ by single cell RNA sequencing and measured SARS-CoV-2-specific T cell and antibody responses between placebo and PEG-IFN-λ-treated patients. PEG-IFN-λ treatment induced interferon stimulated genes in peripheral immune cells expressing IFNLR1, including plasmacytoid dendritic cells and B cells. PEG-IFN-λ did not affect SARS-CoV-2-specific antibody levels or the magnitude of virus-specific T cells. However, we identified delayed T cell responses in older adults, suggesting that PEG-IFN-λ can overcome delays in adaptive immunity to accelerate viral clearance in high-risk patients. Altogether, PEG-IFN-λ offers an early COVID-19 treatment option for outpatients to boost innate antiviral defenses without dampening peripheral adaptive immunity.

2022-10-14 | GSE215814 | GEO

Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity.

Project description:Interferons induced early after SARS-CoV-2 infection are crucial for shaping immunity and preventing severe COVID-19. We previously demonstrated that injection of pegylated interferon-lambda accelerated viral clearance in COVID-19 patients (NCT04354259). To determine if the viral decline is mediated by enhanced immunity, we assess in vivo responses to interferon-lambda by single cell RNA sequencing and measure SARS-CoV-2-specific T cell and antibody responses between placebo and interferon-lambda-treated patients. Here we show that interferon-lambda treatment induces interferon stimulated genes in peripheral immune cells expressing IFNLR1, including plasmacytoid dendritic cells and B cells. Interferon-lambda does not affect SARS-CoV-2-specific antibody levels or the magnitude of virus-specific T cells. However, we identify delayed T cell responses in older adults, suggesting that interferon-lambda can overcome delays in adaptive immunity to accelerate viral clearance in high-risk patients. Altogether, interferon-lambda offers an early COVID-19 treatment option for outpatients to boost innate antiviral defenses without dampening peripheral adaptive immunity.

| S-EPMC9667439 | biostudies-literature

Clearance of p21-highly-expressing senescent cells accelerates wound healing

Project description:Clearance of p21-highly-expressing senescent cells accelerates wound healing

| PRJNA1168086 | ENA

Clearance of p21-highly-expressing senescent cells accelerates cutaneous wound healing

Project description:Clearance of p21-highly-expressing senescent cells accelerates cutaneous wound healing

| PRJNA1167732 | ENA

Identical transcriptome reprograming by interferon lambda 3 and 4 and its absence in IFNLR1 or IL10R2 deficient cells rules out the IFNL4 non-canonical signaling hypothesis

Project description:Lambda interferons IFNL1-3 mediate antiviral immunity by inducing interferon sensitive genes (ISGs) in epithelial tissues. Contrarily, a variant creating the functional gene IFNL4 is associated with impaired clearance of hepatitis C virus (HCV) despite of higher liver expression of ISGs in untreated HCV patients. We aimed to explore IFNL4 signaling mechanism by comparing expression profiles from human hepatic cell line clones with genetic modifications influencing the ISG signaling pathway (IFNLR1/IL10R2 knockouts, IFNL4/IFNL3 expression stimulation by transfection).

2021-12-31 | E-MTAB-8916 | biostudies-arrayexpress

Cigarette smoking prolongs immune responses against influenza and delays its clearance in mice

Project description:Cigarette smoking prolongs immune responses against influenza and delays its clearance in mice

| PRJNA1120769 | ENA

Lambdavirus lambda

Project description:Lambdavirus lambda

| PRJNA388730 | ENA

Lambdavirus lambda

Project description:Speciation phage lambda

| PRJNA353945 | ENA

Lambdavirus lambda

Project description:Lambdavirus lambda Genome sequencing