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Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

ABSTRACT: Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

PROVIDER: PRJNA897009 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22161707_1.fastq.gz	Fastqsanger.gz
	SRR22161707_2.fastq.gz	Fastqsanger.gz
	SRR22161708_1.fastq.gz	Fastqsanger.gz
	SRR22161708_2.fastq.gz	Fastqsanger.gz
	SRR22161709_1.fastq.gz	Fastqsanger.gz

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Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

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Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

Project description:Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chromatin architecture in the immune cells remains unclear, especially for the late stages of T cell subset differentiation and maturation. Regulatory T cells (Treg) are mainly generated in the thymus as a subpopulation of T cells specializing in suppressing excessive immune responses. Here, by comprehensively mapping 3D chromatin organization during Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of Foxp3, a Treg lineage specifying transcription factor, were highly enriched at Treg-specific chromatin loop anchors. Further comparison of the chromatin interactions between wide-type Tregs versus Treg cells from Foxp3 knock-in/knockout or newly-generated Foxp3 domain-swap mutant mouse revealed that Foxp3 was essential for the establishment of Treg-specific 3D chromatin architecture, although it was not dependent on the formation of the Foxp3 domain-swapped dimer. These results highlighted an underappreciated role of Foxp3 in modulating Treg-specific 3D chromatin structure formation.

2023-06-14 | GSE217144 | GEO