Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity.

ABSTRACT: Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chromatin architecture in the immune cells remains unclear, especially for the late stages of T cell subset differentiation and maturation. Regulatory T cells (Treg) are mainly generated in the thymus as a subpopulation of T cells specializing in suppressing excessive immune responses. Here, by comprehensively mapping 3D chromatin organization during Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additional

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10628232 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature