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ABSTRACT: Genome assembly of four bacterial endophytes from cloves of Allium sativum (garlic)

PROVIDER: PRJNA899850 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR22245959_1.fastq.gz	Fastqsanger.gz
	SRR22245959_2.fastq.gz	Fastqsanger.gz
	SRR22245960_1.fastq.gz	Fastqsanger.gz
	SRR22245960_2.fastq.gz	Fastqsanger.gz

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Evaluation of expression profiles due to garlic intake in young men and women.

Project description:Allium sativum (garlic) is considered the source of the diverse beneficial effects on thrombosis, heart disease, diabetes, nerve disorders and cancer, as well as being circulatory strengthening. We describe the global changes in transcriptomic activity from a short period of using a moderate amount of fresh garlic and its potential link to some of the beneficial effects.

2022-12-23 | GSE221486 | GEO

Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver

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Top down analysis of human MT2 modification by ajoen and allicine

Project description:Garlic (Allium sativum) is a widely used culinary ingredient of multiple cuisines. Once disintegrated garlic cloves release volatile sulfur compounds, the so-called garlic organosulfur compounds (GOSC). The most famous of these are allicin and ajoen, known for their antimicrobial properties. These compounds also readily modify human metallothionein proteins. In this study we aimed to identify the reactive sites of allicin and ajoen within the purified human metallothionein 2 (MT2). For this we employed an LC-MS protein top-down analysis.

2025-07-31 | PXD059722 | Pride

Project description:Fusarium proliferatum isolated from Allium sativum (Garlic)

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Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver

Project description:Alcohol induced fatty liver cause a dangerous health problem and is the major cause of morbidity and mortality worldwide. Garlic (Allium sativum) is documented to possess anti-fatty liver properties. However the exact molecular mechanisms are unknown. The main aim of this experiment is to elucidate the underlying pathways through which garlic ameliorates alcohol induced fatty liver. Dially disulfide and garlic oil were the garlic compounds used in this study. Leiber DeCarli ethanol liquid diet was to induce fatty liver in C57BL/6 mice model. Also the expression impaired by alcohol induced fatty liver is another aim of this study. Leiber-Decarli ethanol diet was used to induce fatty liver in male C57BL/6 mice (n=12). For control, Lieber-DeCarli liquid control diet was fed to mice (n=4). The control mice were pair-fed to the ethanol mice. After adaptation, the ethanol fed mice were divided into three groups viz. alcohol (n=4), dially disulfide [DADS] (n=4) and garlic oil [GO] (n=4). The study started with the administration of DADS (15 mg/kg bw) or GO (50 mg/kg bw) mixed in 0.1 ml olive oil through gavage. For the control and alcohol groups, same amount of olive oil (0.1 ml) was gavaged. The mice were gavaged daily for 4 weeks. The mice were euthanized by CO2 and blood was collected by cardiac puncture. Liver, kidney, spleen, lungs and hearts were collected and their weights recorded. A portion of liver was snap frozen in liquid nitrogen (200 mg) for RNA extraction.

2012-10-01 | E-GEOD-40334 | biostudies-arrayexpress

Project description:Fusarium oxysporum isolated from Allium sativum (Garlic) in Australia

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Allium sativum cultivar:Snow Mountain Garlic

Project description:Allium sativum cultivar:Snow Mountain Garlic Transcriptome or Gene expression

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Project description:Allium sativum Genome sequencing and assembly

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The human allicin-proteome: global protein S-thioallylation of by the garlic defence substance allicin and its biological effects

Project description:A single clove of edible garlic (Allium sativum L.) produces up to 5 mg of allicin (diallylthiosulfinate), a thiol-reactive sulfur-containing defence substance that gives injured garlic tissue its characteristic smell. Allicin induces apoptosis or necrosis in a dose-dependent manner but sublethal doses influence cellular metabolism and signalling cascades. Oxidation of protein thiols and depletion of the glutathione pool are thought to be responsible for allicin’s physiological effects. Here, we studied the effect of Allicin on post-translational thiol-modification in human Jurkat cells using shotgun LC-MS/MS analyses. We identified 332 proteins in the human Jurkat cell proteome that were modified by S-thioallylation which causes a mass shift of 72 Dalton on cysteines. Many S-thioallylated proteins are high abundant proteins, including the cytoskeletal proteins tubulin, actin, cofilin, filamin and plastin-2, the heat shock chaperones HSP90 and HSPA4, the glycolytic enzymes GAPDH, ALDOA, PKM as well the protein translation factor EEF2. We confirmed that Allicin disrupted the actin cytoskeleton in mouseL929 fibroblasts. Allicin further resulted in Zn2+ release from proteins and stimulated the Zn2+-dependent IL1-triggered release of IL2 in murine EL4 T-cells. Allicin further caused inhibition of enolase activity. In conclusion, our study revealed the overall extent of widespread S-thioallylation in the human Jurkat cell proteome after allicin exposure which affects essential cellular functions of selected allicin targets.

2018-11-30 | PXD010201 | Pride

Allium sativum

Project description:Allium sativum Transcriptome project

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