Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-Cell RNA Sequencing Analysis of Human Embryonic Stem Cell-Derived Neural Organoids

ABSTRACT: Single-Cell RNA Sequencing Analysis of Human Embryonic Stem Cell-Derived Neural Organoids

PROVIDER: PRJNA903889 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single-Cell RNA Sequencing Analysis of Human Embryonic Stem Cell-Derived Neural Organoids

Project description:Human pluripotent stem cell-derived 3D neural organoids have been shown to recapitulate the major features and cytoarchitecture of early human brain development. We used three commercially available kits: STEMdiff™ Cerebral Organoid Kit, STEMdiff™ Dorsal Forebrain Organoid Differentiation Kit, and STEMdiff™ Ventral Forebrain Organoid Differentiation Kit. These neural organoids contain unique and diverse cell types which model the early brain and are patterned with developmental cues. Here, we sought to investigate the cellular diversity of these organoids using single-cell RNA sequencing.

2023-02-23 | GSE218457 | GEO

Human embryonic stem cell-derived neural crest model for neuroblastoma

Project description:Human embryonic stem cell-derived neural crest model for neuroblastoma

| PRJNA574066 | ENA

SARS-CoV-2 infection of human embryonic stem cell-derived lung organoids

Project description:RNA-seq for SARS-CoV-2 infection of human embryonic stem cell-derived lung organoids

2023-08-05 | GSE155717 | GEO

Hi-C from mouse embryonic stem cell derived neural stem cells

Project description:Hi-C from mouse embryonic stem cell derived neural stem cells

| PRJEB70606 | ENA

DNA methylation in hESC derived brain organoids and iPSC derived neurons, astrocytes and neural progenitors

Project description:We studied the impact of ZIKA virus infection on DNA methylation in whole organoids, organoid derived astrocytes, neurons neural progeniotors and hESC or iPSC derived astrocytes, neurons, neural progenotor cells

2018-01-12 | GSE109104 | GEO

SARS-CoV-2 infection of human embryonic stem cell-derived lung organoids

Project description:SARS-CoV-2 infection of human embryonic stem cell-derived lung organoids

| PRJNA655396 | ENA

Proteomic signatures of schizophrenia-sourced iPSC-derived brain organoids

Project description:Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. Understanding timepoints of disturbances during neural cell differentiation processes could lead to an insight into the development of the disorder. In this context, human brain organoids and neural cells differentiated from patient-derived induced pluripotent stem cells are of great interest as a model to study the developmental origins of the disease. Here we evaluated the differential expression of proteins of schizophrenia patient-derived neural progenitors, early neurons, and brain organoids. Using bottom-up shotgun proteomics with a label-free approach for quantitative analysis. Multiple dysregulated proteins were found in pathways related to synapses, in line with postmortem tissue studies of schizophrenia patients. However, organoids and immature neurons exhibit impairments in pathways never before found in patient-derived induced pluripotent stem cell studies, such as spliceosomes and amino acid metabolism. In conclusion, here we provide comprehensive, large-scale, protein-level data that may uncover underlying mechanisms of the developmental origins of schizophrenia.

2023-03-11 | PXD026381 | Pride

PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm

Project description:PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm

| PRJNA526532 | ENA

Single-Cell RNA Sequencing of Retinal Organoids Derived by CSC14 hESCs

Project description:Retinal organoids samples that derived from human embryonic stem cells were analyzed by single-cell RNA sequencing. Two samples at different differentiation stages (day57 and day 171) were included in this study for cell type comparison.

2022-01-01 | E-MTAB-11121 | biostudies-arrayexpress

Proteomic signatures of schizophrenia-sourced iPSC-derived neural progenitors and neurons

2023-03-11 | PXD026593 | Pride